Phaclofen

Phaclofen

SCHEMBL339995

NCC(CP(=O)(O)O)c1ccc(Cl)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 3/20 1.00
CYP1A2 P05177 2/20 1.00
THRB P10828 2/20 1.00
MAPT P10636 1/20 1.00
PMP22 Q01453 1/20 1.00
SMN1; SMN2 Q16637 1/20 1.00
NPSR1 Q6W5P4 1/20 1.00
GABBR2 O75899 7/20 0.57
GABBR1 Q9UBS5 7/20 0.57
CYP2C9 P11712 2/20 0.57
CYP3A4 P08684 1/20 0.57
ADORA3 P0DMS8 1/20 0.57
NFKB1 P19838 1/20 0.57
DRD3 P35462 1/20 0.57
BLM P54132 1/20 0.57
CYP2D6 P10635 1/20 0.57
CYP2C19 P33261 1/20 0.57
MEN1 O00255 1/20 0.57
TSHR P16473 1/20 0.57
KMT2A Q03164 1/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Phaclofen SCHEMBL10343565 0.98 LMNA (0.97) LMNACYP1A2THRBMAPTPMP22
SCHEMBL1881771 0.86 LMNA (0.76) LMNACYP1A2THRBMAPTPMP22
SCHEMBL1893272 0.86 LMNA (0.76) LMNACYP1A2THRBMAPTPMP22
SCHEMBL1887532 0.86 LMNA (0.76) LMNACYP1A2THRBMAPTPMP22
SCHEMBL6350896 0.81 LMNA (0.68) LMNACYP1A2THRBMAPTPMP22
Phaclofen SCHEMBL10343564 0.81 LMNA (0.68) LMNACYP1A2THRBMAPTPMP22
SCHEMBL10507284 0.78 GABBR2 (0.64) LMNACYP1A2THRBMAPTPMP22
SCHEMBL28002092 0.78 LMNA (0.64) LMNACYP1A2THRBMAPTPMP22
SCHEMBL21616488 0.78 LMNA (0.64) LMNACYP1A2THRBMAPTPMP22
SCHEMBL6361790 0.78 LMNA (0.62) LMNACYP1A2THRBMAPTPMP22

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 341 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240142377-A1 DYES UNDERGOING CHANGES IN COLOR AND FLUORESCENCE UPON BINDING OF ORGANIC OXO COMPOUNDS BUNDESREPUBLIK DEUTSCHLAND, VERTRETEN DURCH DEN BUNDESMINISTER FÜR WIRTSCHAFT UND ENERGIE, DIESER VE (DE) 2024-05-02 US claimed
EP-4255897-A1 DYES UNDERGOING CHANGES IN COLOR AND FLUORESCENCE UPON BINDING OF ORGANIC OXO COMPOUNDS Bundesrepublik Deutschland, vertreten durch den Bundesminister für Wirtschaft und Energie, dieser vertreten durch den Präsidenten der (DE) 2023-10-11 EP claimed
WO-2022122402-A1 DYES UNDERGOING CHANGES IN COLOR AND FLUORESCENCE UPON BINDING OF ORGANIC OXO COMPOUNDS BUNDESREPUBLIK DEUTSCHLAND, VERTRETEN DURCH DEN BUNDESMINISTER FÜR WIRTSCHAFT UND ENERGIE, DIESER VERTRETEN DURCH DEN PRÄSIDENTEN DER BUNDESANSTALT FÜR MATERIALFORSCHUNG UND -PRÜFUNG, (BAM) (DE) 2022-06-16 WO claimed
US-10716779-B2 Methods and compositions for treating foot or hand pain SANDERS JENNIFER L (US) 2020-07-21 US claimed
US-20190083465-A1 Methods And Compositions For Treating Foot Or Hand Pain SANDERS JENNIFER L (US) 2019-03-21 US claimed
US-10195180-B2 Methods and compositions for treating foot or hand pain SANDERS JENNIFER L (US) 2019-02-05 US claimed
WO-2017089804-A1 NOVEL PHARMACEUTICAL COMPOSITIONS OXFORD UNIVERSITY INNOVATION LIMITED (GB) 2017-06-01 WO claimed
CN-100430063-C Combinations using 5-hydroxytryptamine reuptake inhibitors LUNDBECK & CO AS H (DK) 2008-11-05 CN claimed
JP-2007517040-A 2007-06-28 JP claimed
EP-1545552-B1 COMBINATION THERAPY WHEREIN A SEROTONIN REUPTAKE INHIBITOR IS USED LUNDBECK & CO AS H (DK) 2007-03-28 EP claimed
EP-1416794-A2 REGULATION OF PLANT FERTILITY BY MODULATION OF GABA LEVELS IN FLOWERS The University of Chicago (US) 2004-05-12 EP claimed
WO-2004000326-A1 COMBINATION THERAPY WHEREIN A SEROTONIN REUPTAKE INHIBITOR IS USED H. LUNDBECK A/S (DK) 2003-12-31 WO claimed
WO-2003000039-A2 REGULATION OF PLANT FERTILITY BY MODULATION OF GABA LEVELS IN FLOWERS UNIVERSITY OF CHICAGO (US) 2003-01-03 WO claimed
EP-0701438-B1 GABA-ERGIC MODULATION OF EYE GROWTH UNIV PENNSYLVANIA (US) 1999-07-07 EP claimed
EP-0701438-A4 GABA-ERGIC MODULATION OF EYE GROWTH UNIV PENNSYLVANIA (US) 1997-11-19 EP claimed
US-5567731-A Gaba-ergic modulation of eye growth THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) 1996-10-22 US claimed
CN-1122104-A Gaba-Ergic modulation of eye growth UNIV PENNSYLVANIA (US) 1996-05-08 CN claimed
EP-0701438-A1 GABA-ERGIC MODULATION OF EYE GROWTH THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) 1996-03-20 EP claimed
US-5385939-A Preventing the axial elongation myopia in the eye by administering a gama-aminobutyric acid receptor antagonist THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) 1995-01-31 US claimed
WO-1994025018-A1 GABA-ERGIC MODULATION OF EYE GROWTH THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) 1994-11-10 WO claimed