Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OGG1 | O15527 | 1/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.45 |
| ▸ | GRM5 | P41594 | 1/20 | 0.43 |
| ▸ | WDR5 | P61964 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | RXRA | P19793 | 1/20 | 0.41 |
| ▸ | RXRB | P28702 | 1/20 | 0.41 |
| ▸ | RXRG | P48443 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10451483 | 0.83 | OGG1 (0.56) | OGG1SLC6A4GRM5WDR5KMT2A | |
| SCHEMBL31634192 | 0.80 | NPSR1 (0.51) | OGG1SLC6A4GRM5WDR5KMT2A | |
| SCHEMBL6299188 | 0.80 | NPSR1 (0.51) | OGG1SLC6A4GRM5WDR5KMT2A | |
| SCHEMBL105734 | 0.80 | OGG1 (0.57) | OGG1SLC6A4GRM5KMT2AL3MBTL1 | |
| Chloromethane SCHEMBL27541396 | 0.78 | OGG1 (0.56) | OGG1SLC6A4GRM5KMT2AL3MBTL1 | |
| SCHEMBL27550855 | 0.78 | OGG1 (0.51) | OGG1SLC6A4WDR5KMT2AL3MBTL1 | |
| SCHEMBL17032600 | 0.77 | OGG1 (0.54) | OGG1SLC6A4GRM5WDR5KMT2A | |
| SCHEMBL8059974 | 0.77 | OGG1 (0.58) | OGG1SLC6A4GRM5WDR5KMT2A | |
| SCHEMBL10359842 | 0.77 | OGG1 (0.58) | OGG1SLC6A4GRM5WDR5KMT2A | |
| Hydrazine SCHEMBL28120133 | 0.77 | OGG1 (0.58) | OGG1SLC6A4GRM5WDR5KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0191044-B1 | DERIVATIVES OF METHYLENE-BISPHOSPHONIC ACID, PROCESS FOR THEIR PREPARATION AND A PHARMACEUTICAL COMPOSITION | LEO PHARMACEUTICAL PRODUCTS LTD. A/S (LOVENS KEMISKE FABRIK PRODUKTIONSAKTIESELSKAB) (DK) | 1990-02-07 | — | — | EP | disclosed |
| US-4732998-A | Bisphosphonic acids and esters | LEO PHARMACEUTICAL PRODUCTS, LTD. (DK) | 1988-03-22 | — | — | US | disclosed |
| EP-0191044-A1 | DERIVATIVES OF METHYLENE-BISPHOSPHONIC ACID, PROCESS FOR THEIR PREPARATION AND A PHARMACEUTICAL COMPOSITION. | LEO PHARM PROD LTD (DK) | 1986-08-20 | — | — | EP | disclosed |
| WO-1986000902-A1 | DERIVATIVES OF METHYLENE-BISPHOSPHONIC ACID, PROCESS FOR THEIR PREPARATION AND A PHARMACEUTICAL COMPOSITION | LEO PHARMACEUTICAL PRODUCTS LTD. A/S (DK) | 1986-02-13 | — | — | WO | disclosed |