Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.33 |
| ▸ | RELA | Q04206 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | ELANE | P08246 | 3/20 | 0.31 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.31 |
| ▸ | PLA2G5 | P39877 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7851784 | 0.77 | POLB (0.34) | POLBALDH1A1 | |
| SCHEMBL5463530 | 0.74 | MEN1 (0.33) | KMT2A | |
| SCHEMBL31235575 | 0.74 | MT-CO2 (0.33) | POLBALDH1A1KMT2A | |
| SCHEMBL1518987 | 0.74 | ADAM17 (0.32) | POLBALDH1A1ELANEMAPT | |
| SCHEMBL7503088 | 0.74 | KMT2A (0.39) | NFKB1NFKB2RELAALDH1A1KMT2A | |
| SCHEMBL5258129 | 0.73 | HPGD (0.51) | KMT2AMAPT | |
| SCHEMBL2538333 | 0.73 | KMT2A (0.36) | NFKB1NFKB2RELAALDH1A1KMT2A | |
| SCHEMBL11772976 | 0.73 | CHRM2 (0.35) | CHRM2CHRM1CHRM3POLBALDH1A1 | |
| SCHEMBL5257403 | 0.72 | HSD17B10 (0.50) | ALDH1A1KMT2A | |
| SCHEMBL5256483 | 0.72 | HSD17B10 (0.50) | ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0137361-B1 | INSULIN DERIVATIVES MODIFIED IN POSITION B 30, PROCESS FOR THEIR PREPARATION, THEIR VUSE AND PHARMACEUTICAL AGENTS FOR THE TREATMENT OF DIABETES MELLITUS | HOECHST AKTIENGESELLSCHAFT (DE) | 1990-05-16 | — | — | EP | disclosed |
| US-4701440-A | SUSTAINED RELEASE | HOECHST AKTIENGESELLSCHAFT (DE) | 1987-10-20 | — | — | US | disclosed |
| EP-0132770-B1 | INSULIN DERIVATIVES, PROCESSES FOR THEIR PREPARATION, THEIR USE AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF DIABETES MELLITUS | HOECHST AKTIENGESELLSCHAFT (DE) | 1987-09-16 | — | — | EP | disclosed |
| EP-0137361-A2 | Insulin derivatives modified in position B 30, process for their preparation, their vuse and pharmaceutical agents for the treatment of diabetes mellitus | HOECHST AKTIENGESELLSCHAFT (DE) | 1985-04-17 | — | — | EP | disclosed |
| EP-0132770-A1 | Insulin derivatives, processes for their preparation, their use and pharmaceutical compositions for the treatment of diabetes mellitus | HOECHST AKTIENGESELLSCHAFT (DE) | 1985-02-13 | — | — | EP | disclosed |
| US-4029642-A | CONDENSATION OF DES-B OCTAPEPTIDE WITH A PEPTIDE | HOECHST AKTIENGESELLSCHAFT (DT) | 1977-06-14 | — | — | US | disclosed |