Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 7/20 | 0.55 |
| ▸ | AKR1A1 | P14550 | 3/20 | 0.43 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.43 |
| ▸ | GSK3A | P49840 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.39 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.39 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10345954 | 0.85 | AKR1B1 (0.55) | AKR1B1AKR1A1GSK3AGSK3BCDK5 | |
| SCHEMBL9672258 | 0.84 | PDK2 (0.44) | PDK2 | |
| SCHEMBL9672018 | 0.83 | AKR1B1 (0.69) | AKR1B1AKR1A1AKR1B10 | |
| SCHEMBL9671705 | 0.82 | AKR1B1 (0.61) | AKR1B1AKR1A1AKR1B10PDK2 | |
| SCHEMBL9751299 | 0.81 | AKR1B1 (0.39) | AKR1B1GSK3AGSK3BPDK2 | |
| SCHEMBL10929989 | 0.80 | AKR1B1 (0.56) | AKR1B1AKR1A1AKR1B10PDK2 | |
| SCHEMBL9672965 | 0.78 | AKR1B1 (0.56) | AKR1B1AKR1A1AKR1B10GSK3AGSK3B | |
| SCHEMBL18462213 | 0.76 | PDK2 (0.40) | AKR1B1GSK3AGSK3BCDK5CDK5R1 | |
| SCHEMBL10929003 | 0.76 | AKR1B1 (0.60) | AKR1B1AKR1A1AKR1B10 | |
| SCHEMBL9672105 | 0.74 | AKR1A1 (0.68) | AKR1B1AKR1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4609663-A | Aldose reductase inhibitors useful in glaucoma therapy | ALCON LABORATORIES, INC. (US) | 1986-09-02 | — | — | US | claimed |
| EP-0258476-B1 | ALDOSE REDUCTASE INHIBITORS USEFUL IN GLAUCOMA THERAPY | ALCON LABORATORIES, INC. (US) | 1990-04-25 | — | — | EP | disclosed |
| US-4609663-A | Aldose reductase inhibitors useful in glaucoma therapy | ALCON LABORATORIES, INC. (US) | 1986-09-02 | — | — | US | disclosed |