Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 4/20 | 0.55 |
| ▸ | GSK3A | P49840 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | AKR1A1 | P14550 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.37 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.37 |
| ▸ | DRD1 | P21728 | 1/20 | 0.37 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10345515 | 0.85 | AKR1B1 (0.55) | AKR1B1GSK3AGSK3BAKR1A1CDK5 | |
| SCHEMBL9672258 | 0.84 | PDK2 (0.44) | MEN1KMT2APDK2 | |
| SCHEMBL9751299 | 0.81 | AKR1B1 (0.39) | AKR1B1GSK3AGSK3BKMT2ACCNB2 | |
| SCHEMBL10930896 | 0.80 | AKR1B1 (0.56) | AKR1B1AKR1A1KMT2ACYP11B2CYP11B1 | |
| SCHEMBL10907091 | 0.74 | AKR1B1 (0.68) | AKR1B1AKR1A1MEN1LMNAADRB2 | |
| SCHEMBL9672186 | 0.73 | AKR1B1 (0.56) | AKR1B1GSK3BAKR1A1CCNB2CDK1 | |
| SCHEMBL8804611 | 0.71 | AKR1B1 (1.00) | AKR1B1AKR1A1 | |
| SCHEMBL2483457 | 0.70 | AKR1B1 (0.56) | AKR1B1MEN1HTR1AHTR2AHTR6 | |
| SCHEMBL22609096 | 0.70 | PDK2 (0.44) | AKR1B1AKR1A1MEN1LMNAADRB2 | |
| SCHEMBL29395626 | 0.70 | PDK2 (0.44) | AKR1B1AKR1A1MEN1LMNAADRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4609663-A | Aldose reductase inhibitors useful in glaucoma therapy | ALCON LABORATORIES, INC. (US) | 1986-09-02 | — | — | US | claimed |
| EP-0258476-B1 | ALDOSE REDUCTASE INHIBITORS USEFUL IN GLAUCOMA THERAPY | ALCON LABORATORIES, INC. (US) | 1990-04-25 | — | — | EP | disclosed |
| US-4609663-A | Aldose reductase inhibitors useful in glaucoma therapy | ALCON LABORATORIES, INC. (US) | 1986-09-02 | — | — | US | disclosed |