Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 8/20 | 0.56 |
| ▸ | AKR1A1 | P14550 | 4/20 | 0.44 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.44 |
| ▸ | GSK3A | P49840 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.37 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9672018 | 0.87 | AKR1B1 (0.69) | AKR1B1AKR1A1AKR1B10CYP1A2MAPT | |
| SCHEMBL9671705 | 0.81 | AKR1B1 (0.61) | AKR1B1AKR1A1AKR1B10 | |
| SCHEMBL10929003 | 0.80 | AKR1B1 (0.60) | AKR1B1AKR1A1AKR1B10CYP1A2MAPT | |
| SCHEMBL10345515 | 0.78 | AKR1B1 (0.55) | AKR1B1AKR1A1AKR1B10GSK3AGSK3B | |
| SCHEMBL21844215 | 0.76 | AKR1B1 (0.62) | AKR1B1AKR1A1AKR1B10 | |
| SCHEMBL10929989 | 0.76 | AKR1B1 (0.56) | AKR1B1AKR1A1AKR1B10CYP1A2MAPT | |
| SCHEMBL9673456 | 0.75 | AKR1B1 (0.57) | AKR1B1AKR1A1AKR1B10CYP1A2MAPT | |
| SCHEMBL10930198 | 0.73 | AKR1B1 (0.55) | AKR1B1AKR1A1AKR1B10 | |
| SCHEMBL9672056 | 0.72 | AKR1A1 (0.76) | AKR1B1AKR1A1 | |
| SCHEMBL10975155 | 0.72 | AKR1B1 (0.51) | AKR1B1AKR1A1AKR1B10MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5153211-A | Enzyme inhibitors | ALCON LABORATORIES, INC. (US) | 1992-10-06 | — | — | US | disclosed |
| US-5070100-A | COMPLICATIONS OF DIABETES | ALCON LABORATORIES, INC. (US) | 1991-12-03 | — | — | US | disclosed |
| US-4864028-A | ANTIDIABETIC AGENTS | ALCON LABORATORIES, INC. (US) | 1989-09-05 | — | — | US | disclosed |
| US-4537892-A | ANTIDIABETIC AGENTS | ALCON LABORATORIES, INC. (US) | 1985-08-27 | — | — | US | disclosed |
| EP-0137333-A2 | Spiro-tricyclicaromatic succinimide derivatives as inhibitors of aldose reductase | ALCON LABORATORIES, INC. (US) | 1985-04-17 | — | — | EP | disclosed |