Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 0.55 |
| ▸ | LMNA | P02545 | 5/20 | 0.55 |
| ▸ | RAB9A | P51151 | 7/20 | 0.49 |
| ▸ | NPC1 | O15118 | 5/20 | 0.49 |
| ▸ | TSHR | P16473 | 4/20 | 0.49 |
| ▸ | TP53 | P04637 | 3/20 | 0.49 |
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.41 |
| ▸ | USP2 | O75604 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1031306 | 0.88 | MAPT (0.48) | MAPTLMNARAB9ANPC1TSHR | |
| SCHEMBL1033367 | 0.86 | LMNA (0.56) | MAPTLMNARAB9ANPC1TSHR | |
| SCHEMBL1036722 | 0.85 | MAPT (0.56) | MAPTLMNARAB9ANPC1TSHR | |
| SCHEMBL1035429 | 0.83 | MAPT (0.65) | MAPTLMNARAB9ANPC1TSHR | |
| SCHEMBL1032638 | 0.78 | MAPT (0.46) | MAPTLMNARAB9ANPC1TSHR | |
| SCHEMBL1036696 | 0.75 | MAPT (0.58) | MAPTLMNARAB9ANPC1TSHR | |
| SCHEMBL1034966 | 0.72 | LMNA (0.57) | MAPTLMNARAB9ANPC1TSHR | |
| SCHEMBL1034956 | 0.71 | TP53 (0.56) | MAPTLMNARAB9ANPC1TSHR | |
| SCHEMBL10077922 | 0.71 | MAPT (1.00) | MAPTLMNARAB9ANPC1TSHR | |
| SCHEMBL1035487 | 0.71 | MAPT (0.54) | MAPTLMNARAB9ANPC1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2086537-B1 | IMIDAZO[2,1-B]THIAZOLES AND THEIR USE AS PHARMACEUTICALS | SANOFI AVENTIS (FR) | 2011-01-26 | — | — | EP | claimed |