Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 15/20 | 1.00 |
| ▸ | LMNA | P02545 | 5/20 | 1.00 |
| ▸ | TSHR | P16473 | 7/20 | 0.78 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.78 |
| ▸ | HTT | P42858 | 5/20 | 0.78 |
| ▸ | USP2 | O75604 | 4/20 | 0.78 |
| ▸ | RAB9A | P51151 | 3/20 | 0.78 |
| ▸ | NPC1 | O15118 | 2/20 | 0.78 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.72 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.72 |
| ▸ | HPGD | P15428 | 5/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.72 |
| ▸ | POLB | P06746 | 1/20 | 0.72 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.70 |
| ▸ | TP53 | P04637 | 3/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.64 |
| ▸ | MEN1 | O00255 | 3/20 | 0.64 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.63 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16689211 | 0.82 | TSHR (0.75) | MAPTLMNATSHRSMN1; SMN2HTT | |
| SCHEMBL1034707 | 0.81 | LMNA (0.85) | MAPTLMNATSHRSMN1; SMN2HTT | |
| SCHEMBL1035429 | 0.79 | MAPT (0.65) | MAPTLMNATSHRSMN1; SMN2HTT | |
| SCHEMBL1035519 | 0.74 | MAPT (0.69) | MAPTLMNATSHRSMN1; SMN2HTT | |
| SCHEMBL1034600 | 0.71 | MAPT (0.55) | MAPTLMNATSHRSMN1; SMN2HTT | |
| SCHEMBL5553168 | 0.68 | RAB9A (0.65) | MAPTLMNATSHRSMN1; SMN2HTT | |
| SCHEMBL27361298 | 0.68 | RAB9A (0.57) | MAPTLMNATSHRSMN1; SMN2HTT | |
| SCHEMBL19995013 | 0.68 | GHSR (1.00) | MAPTLMNATSHRSMN1; SMN2ALDH1A1 | |
| SCHEMBL1033769 | 0.68 | MAPT (0.78) | MAPTLMNATSHRSMN1; SMN2USP2 | |
| SCHEMBL1034706 | 0.67 | TP53 (1.00) | MAPTLMNATSHRSMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012016133-A2 | ROS1 KINASE INHIBITORS FOR THE TREATMENT OF GLIOBLASTOMA AND OTHER P53-DEFICIENT CANCERS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2012-02-02 | — | — | WO | disclosed |