Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.56 |
| ▸ | RAB9A | P51151 | 6/20 | 0.56 |
| ▸ | NPC1 | O15118 | 5/20 | 0.56 |
| ▸ | HPGD | P15428 | 4/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.52 |
| ▸ | LMNA | P02545 | 6/20 | 0.52 |
| ▸ | TSHR | P16473 | 5/20 | 0.52 |
| ▸ | HTT | P42858 | 3/20 | 0.52 |
| ▸ | USP2 | O75604 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.48 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1031306 | 0.91 | MAPT (0.48) | MAPTRAB9ANPC1HPGDCYP1A2 | |
| SCHEMBL1033367 | 0.88 | LMNA (0.56) | MAPTRAB9ANPC1HPGDSMN1; SMN2 | |
| SCHEMBL1032638 | 0.87 | MAPT (0.46) | MAPTRAB9ANPC1HPGDCYP1A2 | |
| SCHEMBL1034600 | 0.85 | MAPT (0.55) | MAPTRAB9ANPC1HPGDCYP1A2 | |
| SCHEMBL1035519 | 0.81 | MAPT (0.69) | MAPTRAB9ANPC1HPGDCYP1A2 | |
| SCHEMBL974926 | 0.75 | MAPT (0.57) | MAPTRAB9ANPC1HPGDCYP1A2 | |
| SCHEMBL1035662 | 0.73 | LMNA (0.57) | MAPTRAB9ANPC1HPGDSMN1; SMN2 | |
| SCHEMBL5553168 | 0.73 | RAB9A (0.65) | MAPTRAB9ANPC1HPGDCYP1A2 | |
| SCHEMBL1036696 | 0.73 | MAPT (0.58) | MAPTRAB9ANPC1HPGDSMN1; SMN2 | |
| SCHEMBL1035981 | 0.73 | TP53 (0.70) | MAPTRAB9ANPC1HPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2086537-B1 | IMIDAZO[2,1-B]THIAZOLES AND THEIR USE AS PHARMACEUTICALS | SANOFI AVENTIS (FR) | 2011-01-26 | — | — | EP | claimed |