Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | HTR6 | P50406 | 5/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.39 |
| ▸ | FPR1 | P21462 | 1/20 | 0.39 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.38 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1036352 | 0.81 | HTR6 (0.46) | KDM4ESMN1; SMN2NPC1MAPTRAB9A | |
| SCHEMBL1032349 | 0.81 | KDM4E (0.48) | KDM4ESMN1; SMN2NPC1MAPTRAB9A | |
| SCHEMBL1031662 | 0.77 | HTR6 (0.45) | HTR6ACHE | |
| SCHEMBL1031317 | 0.76 | KDM4E (0.40) | KDM4ESMN1; SMN2NPC1MAPTRAB9A | |
| SCHEMBL1035014 | 0.76 | KDM4E (0.40) | KDM4ESMN1; SMN2NPC1MAPTRAB9A | |
| SCHEMBL1034950 | 0.76 | SMN1; SMN2 (0.46) | KDM4ESMN1; SMN2NPC1MAPTRAB9A | |
| SCHEMBL1035442 | 0.75 | ALDH1A1 (0.43) | KDM4EMAPTALDH1A1TSHRLMNA | |
| SCHEMBL1034399 | 0.72 | LMNA (0.44) | KDM4ESMN1; SMN2HTR6ALDH1A1TSHR | |
| SCHEMBL1035672 | 0.65 | ALDH1A1 (0.44) | KDM4ESMN1; SMN2MAPTHTR6ALDH1A1 | |
| SCHEMBL1032534 | 0.62 | HPGD (0.53) | KDM4ESMN1; SMN2NPC1MAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8268845-B2 | Tetrahydro- and dihydroquinazolinones | MERCK PATENT GMBH (DE) | 2012-09-18 | — | — | US | disclosed |
| US-20110195965-A1 | TETRAHYDRO- AND DIHYDROQUINAZOLINONES | FINSINGER DIRK | 2011-08-11 | — | — | US | disclosed |
| EP-1856061-B1 | TETRAHYDRO- AND DIHYDROQUINAZOLINONES | MERCK PATENT GMBH (DE) | 2011-01-26 | — | — | EP | disclosed |
| US-20090318444-A1 | TETRAHYDRO- AND DIHYDROQUINAZOLINONES | MERCK PATENT GMBH (DE) | 2009-12-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110195965-A1 | TETRAHYDRO- AND DIHYDROQUINAZOLINONES | CSNK1A1, MAP3K19, CSNK1E | KDM4E 1799/4885SMN1; SMN2 2668/4885NPC1 1578/4885 |
| US-20090318444-A1 | TETRAHYDRO- AND DIHYDROQUINAZOLINONES | CSNK1A1, MAP3K19, DMPK | KDM4E 1861/4885SMN1; SMN2 2725/4885NPC1 1722/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.