Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A known ✓ | P08908 | 2/20 | 0.57 |
| ▸ | HTR1D known ✓ | P28221 | 7/20 | 0.43 |
| ▸ | HTR1B known ✓ | P28222 | 6/20 | 0.43 |
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.38 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7510223 | 0.99 | HTR1A (0.58) | HTR1AHTR1DHTR1BMTNR1AMTNR1B | |
| Oxalic Acid SCHEMBL7512423 | 0.95 | HTR1A (0.55) | HTR1AHTR1DHTR1BMTNR1AMTNR1B | |
| Sulfuric Acid SCHEMBL7514020 | 0.94 | HTR1A (0.54) | HTR1AHTR1DHTR1BMTNR1AMTNR1B | |
| SCHEMBL7516412 | 0.88 | HTR1A (0.60) | HTR1AHTR1DHTR1BDRD2SLC6A4 | |
| SCHEMBL8893706 | 0.87 | HTR1A (0.59) | HTR1AHTR1DHTR1BMTNR1AMTNR1B | |
| Iodide SCHEMBL7514820 | 0.87 | HTR1A (0.59) | HTR1AHTR1DHTR1BDRD2SLC6A4 | |
| Citric Acid SCHEMBL7518930 | 0.86 | HTR1A (0.49) | HTR1AHTR1DHTR1BDRD2SLC6A4 | |
| SCHEMBL7509146 | 0.85 | HTR1A (0.67) | HTR1AHTR1DHTR1BDRD2SLC6A4 | |
| Bromide SCHEMBL7511914 | 0.85 | HTR1A (0.80) | HTR1AHTR1DHTR1BDRD2 | |
| SCHEMBL7511060 | 0.85 | HTR1A (0.66) | HTR1AHTR1DHTR1BDRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0153083-B1 | 6-SUBSTITUTED-4-DIALKYLAMINOTETRAHYDROBENZ(C,D)INDOLES | ELI LILLY AND COMPANY (US) | 1990-05-23 | — | — | EP | disclosed |
| US-4576959-A | ANTIDEPRESSANTS | ELI LILLY AND COMPANY (US) | 1986-03-18 | — | — | US | disclosed |
| EP-0153083-A2 | 6-Substituted-4-dialkylaminotetrahydrobenz(c,d)indoles | ELI LILLY AND COMPANY (US) | 1985-08-28 | — | — | EP | disclosed |