Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 3/20 | 0.49 |
| ▸ | HTR1D | P28221 | 7/20 | 0.38 |
| ▸ | HTR1B | P28222 | 6/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.37 |
| ▸ | DRD2 | P14416 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL9641269 | 0.89 | HTR1A (0.66) | HTR1AHTR1DHTR1BSLC6A4DRD2 | |
| SCHEMBL7510223 | 0.87 | HTR1A (0.58) | HTR1AHTR1DHTR1BSLC6A4DRD2 | |
| Oxalic Acid SCHEMBL7512423 | 0.86 | HTR1A (0.55) | HTR1AHTR1DHTR1BSLC6A4DRD2 | |
| Bromide SCHEMBL10347607 | 0.86 | HTR1A (0.57) | HTR1AHTR1DHTR1BSLC6A4DRD2 | |
| Sulfuric Acid SCHEMBL7514020 | 0.83 | HTR1A (0.54) | HTR1AHTR1DHTR1BSLC6A4DRD2 | |
| SCHEMBL7516412 | 0.80 | HTR1A (0.60) | HTR1AHTR1DHTR1BSLC6A4DRD2 | |
| Iodide SCHEMBL7514820 | 0.79 | HTR1A (0.59) | HTR1AHTR1DHTR1BSLC6A4DRD2 | |
| SCHEMBL7509146 | 0.78 | HTR1A (0.67) | HTR1AHTR1DHTR1BSLC6A4DRD2 | |
| Acetic Acid SCHEMBL7515123 | 0.77 | HTR1A (0.66) | HTR1AHTR1DHTR1BSLC6A4DRD2 | |
| SCHEMBL7511060 | 0.77 | HTR1A (0.66) | HTR1AHTR1DHTR1BDRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1166783-A2 | Tetrahydrobenz[CD]indole-6-carboxamides for treating sexual dysfunction | ELI LILLY AND COMPANY (US) | 2002-01-02 | — | — | EP | disclosed |
| EP-0633023-A2 | Preventing emesis and treating sexual dysfunction using tetrahydrobenz CD indole-6-carboxamides | ELI LILLY AND COMPANY (US) | 1995-01-11 | — | — | EP | disclosed |
| EP-0285278-B1 | The use of tetrahydrobenz[C,D]indole-6-carboxamides for the preparation of a medicament for the treating anxiety | ELI LILLY AND COMPANY (US) | 1992-08-12 | — | — | EP | disclosed |
| US-4745126-A | Method of treating anxiety with tetrahydrobenz[c,d]indole-6-carboxamides | ELI LILLY AND COMPANY (US) | 1988-05-17 | — | — | US | disclosed |