Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Sulfuric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 2/20 | 0.54 |
| ▸ | HTR1D | P28221 | 7/20 | 0.41 |
| ▸ | HTR1B | P28222 | 6/20 | 0.41 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.38 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 2/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL10347607 | 0.94 | HTR1A (0.57) | HTR1AHTR1DHTR1BMTNR1AMTNR1B | |
| Sulfuric Acid SCHEMBL7524443 | 0.90 | HTR1A (0.56) | HTR1AHTR1DHTR1BDRD2SLC6A4 | |
| Sulfuric Acid SCHEMBL10347223 | 0.86 | HTR1A (0.75) | HTR1AHTR1DHTR1BDRD2 | |
| SCHEMBL7516412 | 0.85 | HTR1A (0.60) | HTR1AHTR1DHTR1BDRD2SLC6A4 | |
| Sulfuric Acid SCHEMBL10347307 | 0.84 | HTR1A (0.46) | HTR1AHTR1DHTR1BMTNR1AMTNR1B | |
| SCHEMBL8893706 | 0.84 | HTR1A (0.59) | HTR1AHTR1DHTR1BMTNR1AMTNR1B | |
| Iodide SCHEMBL7514820 | 0.84 | HTR1A (0.59) | HTR1AHTR1DHTR1BDRD2SLC6A4 | |
| Citric Acid SCHEMBL7518930 | 0.83 | HTR1A (0.49) | HTR1AHTR1DHTR1BDRD2SLC6A4 | |
| SCHEMBL7509059 | 0.82 | HTR1A (0.48) | HTR1AHTR1DHTR1BMTNR1AMTNR1B | |
| SCHEMBL7509146 | 0.82 | HTR1A (0.67) | HTR1AHTR1DHTR1BDRD2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1166783-A2 | Tetrahydrobenz[CD]indole-6-carboxamides for treating sexual dysfunction | ELI LILLY AND COMPANY (US) | 2002-01-02 | — | — | EP | disclosed |
| EP-0633023-A2 | Preventing emesis and treating sexual dysfunction using tetrahydrobenz CD indole-6-carboxamides | ELI LILLY AND COMPANY (US) | 1995-01-11 | — | — | EP | disclosed |
| EP-0285278-B1 | The use of tetrahydrobenz[C,D]indole-6-carboxamides for the preparation of a medicament for the treating anxiety | ELI LILLY AND COMPANY (US) | 1992-08-12 | — | — | EP | disclosed |
| US-4745126-A | Method of treating anxiety with tetrahydrobenz[c,d]indole-6-carboxamides | ELI LILLY AND COMPANY (US) | 1988-05-17 | — | — | US | disclosed |