⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9740421 | 0.80 | — | — | |
| SCHEMBL13221904 | 0.79 | CHRNB2 (0.36) | — | |
| SCHEMBL11437545 | 0.79 | TSHR (0.50) | — | |
| SCHEMBL143364 | 0.79 | TSHR (0.50) | — | |
| SCHEMBL12207083 | 0.78 | CTSK (0.42) | — | |
| SCHEMBL12233188 | 0.78 | CHRNB2 (0.36) | — | |
| SCHEMBL19170549 | 0.78 | CHRNB2 (0.36) | — | |
| SCHEMBL21707840 | 0.78 | — | — | |
| SCHEMBL20807295 | 0.78 | — | — | |
| SCHEMBL11171403 | 0.78 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 397 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210198203-A1 | COMPOUNDS, COMPOSITIONS AND METHODS | CYTOKINETICS, INCORPORATED | 2021-07-01 | — | — | US | claimed |
| CN-108602821-B | 1H-imidazo [4,5-B ] pyridinyl BET bromodomain inhibitors | 恒元生物医药科技(苏州)有限公司 | 2021-06-29 | — | — | CN | claimed |
| CN-107250079-B | Levelling compounds, their use and manufacture | 圣戈班韦伯有限责任公司 | 2020-10-30 | — | — | CN | claimed |
| EP-2903979-B1 | NOVEL COMPOUNDS, THEIR PREPARATION AND THEIR USES | INHIBIKASE THERAPEUTICS INC (US) | 2020-08-19 | — | — | EP | claimed |
| CN-107207472-B | Inhibitors of AKT kinase | 卑尔根生物股份公司 | 2020-08-14 | — | — | CN | claimed |
| US-20190352267-A1 | COMPOUNDS, COMPOSITIONS AND METHODS | CYTOKINETICS, INCORPORATED | 2019-11-21 | — | — | US | claimed |
| CN-109743875-A | The inhibitor of MENIN-MLL interaction | 生命医药公司 | 2019-05-10 | — | — | CN | claimed |
| US-20180305316-A1 | COMPOUNDS, COMPOSITIONS AND METHODS | CYTOKINETICS, INCORPORATED | 2018-10-25 | — | — | US | claimed |
| CN-108602821-A | 1H-imidazo [4,5-B ] pyridinyl and 2-oxo-2, 3-dihydro-1H-imidazo [4,5-B ] pyridinyl heterocycle BET bromodomain inhibitors | 齐尼思表观遗传学有限公司 | 2018-09-28 | — | — | CN | claimed |
| CN-107207472-A | Inhibitors of AKT kinase | 卑尔根生物股份公司 | 2017-09-26 | — | — | CN | claimed |
| US-20070066626-A1 | Compounds, compositions and methods | CYTOKINETICS, INCORPORATED | 2007-03-22 | — | — | US | claimed |
| US-20060128642-A1 | 9-Ketospinosyn derivatives | BAYER CROPSCIENCE AG (DE) | 2006-06-15 | — | — | US | claimed |
| WO-2006009726-A2 | SUBSTITUTED UREA DERIVATIVES FOR TREATING CARDIAC DISEASES | CYTOKINETICS, INC. (US) | 2006-01-26 | — | — | WO | claimed |
| US-20060014761-A1 | Substituted urea derivatives activate the cardiac sarcomere by potentiating cardiac myosin; systolic heart failure including congestive heart failure; 4-[(3-fluoro-5-{[(6-methyl(3-pyridyl))amino]carbonylamino}-phenyl)methyl]piperazinecarboxylate | CYTOKINETICS, INCORPORATED | 2006-01-19 | — | — | US | claimed |
| EP-1590358-A1 | 9-KETOSPINOSYN DERIVATIVES | Bayer CropScience Aktiengesellschaft (DE) | 2005-11-02 | — | — | EP | claimed |
| WO-2005016883-A2 | ACRYLAMIDE DERIVATIVES AS VLA-1 INTEGRIN ANTAGONISTS AND USES THEREOF | ICOS CORPORATION (US) | 2005-02-24 | — | — | WO | claimed |
| WO-2004065402-A1 | 9-KETOSPINOSYN DERIVATIVES | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2004-08-05 | — | — | WO | claimed |
| US-5763614-A | VASODILATION BASED ON CALCIUM ANTAGONISM AND PAF ANTAGONISM | FUJIREBIO INC. (JP) | 1998-06-09 | — | — | US | claimed |
| EP-0033088-B1 | ANTIMYCOTIC AGENTS | BAYER AG (DE) | 1983-05-25 | — | — | EP | claimed |
| EP-0033088-A2 | Antimycotic agents | BAYER AG (DE) | 1981-08-05 | — | — | EP | claimed |