SCHEMBL10348682

SCHEMBL10348682

O=CC1c2ccccc2-c2cc3ccccc3cc21

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PPIA P62937 1/20 0.39
ALDH1A1 P00352 3/20 0.36
TP53 P04637 3/20 0.36
HSD17B10 Q99714 3/20 0.36
HPGD P15428 2/20 0.36
MAPK1 P28482 2/20 0.36
TSHR P16473 1/20 0.36
CASP1 P29466 1/20 0.36
CASP7 P55210 1/20 0.36
HIF1A Q16665 1/20 0.36
KDM4E B2RXH2 2/20 0.33
MEN1 O00255 2/20 0.33
CYP3A4 P08684 2/20 0.33
MAPT P10636 2/20 0.33
KMT2A Q03164 2/20 0.33
SMN1; SMN2 Q16637 2/20 0.33
CYP2D6 P10635 1/20 0.33
CYP2C9 P11712 1/20 0.33
CYP2C19 P33261 1/20 0.33
CA1 P00915 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL224931 0.84 GPR3 (0.41) ALDH1A1TSHRMEN1KMT2ACYP2D6
SCHEMBL29711937 0.84 GPR3 (0.41) ALDH1A1TSHRMEN1KMT2ACYP2D6
SCHEMBL11483825 0.82 CYP2A6 (0.36) ALDH1A1TP53HSD17B10HPGDMAPK1
SCHEMBL27818816 0.82 GPR3 (0.39) ALDH1A1TSHRMEN1KMT2ACYP2D6
Hydrochloric Acid SCHEMBL27768859 0.82 GPR3 (0.39) ALDH1A1TSHRMEN1KMT2ACYP2D6
SCHEMBL28243519 0.80 HTR2A (0.34) ALDH1A1CA1CA2HDAC3HDAC4
Methylamine SCHEMBL27789000 0.78 GPR3 (0.41) TP53HSD17B10MAPK1MEN1CYP3A4
SCHEMBL27389792 0.78 ALDH1A1 (0.45) ALDH1A1TP53HSD17B10HPGDMAPK1
SCHEMBL8518637 0.76 ALDH1A1 (0.44) ALDH1A1TP53HSD17B10HPGDMAPK1
SCHEMBL15048581 0.76 CYP1A2 (0.45) ALDH1A1MAPK1MEN1KMT2ACYP2A6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0182609-B1 POLYCYCLIC BIOCIDAL COMPOUNDS, THEIR SYNTHESIS, FORMULATIONS CONTAINING THEM THE WELLCOME FOUNDATION LIMITED (GB) 1990-05-09 EP disclosed