Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | DRD1 | P21728 | 3/20 | 0.33 |
| ▸ | AR | P10275 | 7/20 | 0.32 |
| ▸ | RAF1 | P04049 | 2/20 | 0.31 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.31 |
| ▸ | CASP3 | P42574 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.30 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.30 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10352216 | 0.95 | AR (0.34) | KDRDRD1ARRAF1CYP19A1 | |
| SCHEMBL10352221 | 0.88 | AR (0.36) | ARCYP19A1SMN1; SMN2 | |
| SCHEMBL10352425 | 0.81 | AR (0.32) | AR | |
| SCHEMBL21610164 | 0.78 | KDR (0.36) | KDRDRD1ARRAF1CYP19A1 | |
| SCHEMBL10352797 | 0.78 | MAOB (0.33) | — | |
| SCHEMBL10353036 | 0.77 | LMNA (0.41) | ARRAF1SMN1; SMN2 | |
| SCHEMBL10352424 | 0.76 | AR (0.36) | ARCYP19A1 | |
| SCHEMBL10352806 | 0.74 | CYP19A1 (0.51) | KDRDRD1ARCYP19A1SMN1; SMN2 | |
| SCHEMBL10352215 | 0.73 | CYP19A1 (0.47) | ARCYP19A1SMN1; SMN2 | |
| SCHEMBL10352218 | 0.70 | AR (0.34) | ARCYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8222403-B2 | Heteroaromatic phthalonitriles | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF THE NAVY (US) | 2012-07-17 | — | — | US | disclosed |
| US-20110108755-A1 | HETEROAROMATIC PHTHALONITRILES | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF THE NAVY (US) | 2011-05-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110108755-A1 | HETEROAROMATIC PHTHALONITRILES | ARNT, PBRM1, NR4A1 | KDR 2709/4885DRD1 606/4885AR 14/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.