Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | TNF | P01375 | 2/20 | 0.46 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.46 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.46 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.46 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.46 |
| ▸ | GALR3 | O60755 | 1/20 | 0.46 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | PDE6D | O43924 | 1/20 | 0.44 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.44 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10353137 | 0.84 | KMT2A (0.71) | KMT2ATNFCXCL8SOS1NOD2 | |
| SCHEMBL10353246 | 0.84 | TNF (0.52) | KMT2ATNFCXCL8SOS1NOD2 | |
| SCHEMBL10353245 | 0.83 | RAB9A (0.43) | KMT2ATNFCXCL8SOS1NOD2 | |
| SCHEMBL10353115 | 0.83 | KMT2A (0.48) | KMT2ATNFCXCL8SOS1NOD2 | |
| SCHEMBL10353872 | 0.82 | RAB9A (0.50) | KMT2ATNFCXCL8SOS1NOD2 | |
| SCHEMBL5199559 | 0.82 | TNF (0.65) | KMT2ATNFALDH1A1MEN1LMNA | |
| SCHEMBL10353130 | 0.78 | HTT (0.54) | KMT2ATNFCXCL8SOS1NOD2 | |
| SCHEMBL9537915 | 0.77 | RAB9A (0.65) | KMT2ARAB9AALDH1A1MEN1LMNA | |
| SCHEMBL13258286 | 0.77 | TP53 (0.67) | KMT2ATNFGALR3NR2F2RAB9A | |
| SCHEMBL10353551 | 0.77 | MAPT (0.63) | KMT2ATNFCXCL8SOS1NOD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0190817-B1 | DOPAMINE-BETA-HYDROXYLASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1990-09-05 | — | — | EP | claimed |
| EP-0190817-A1 | Dopamine-beta-hydroxylase inhibitors | SMITHKLINE BEECHAM CORPORATION (US) | 1986-08-13 | — | — | EP | claimed |
| EP-0190817-B1 | DOPAMINE-BETA-HYDROXYLASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1990-09-05 | — | — | EP | disclosed |
| US-4857540-A | 1-SUBSTITUTED-2-MERCAPTO-(OR AMINOMETHYL-)BENZAMIDAZOLE COMPOUNDS | SMITHKLINE BECKMAN CORPORATION (US) | 1989-08-15 | — | — | US | disclosed |
| US-4728741-A | DOPAMINE BETA-HYDROXYLASE INHIBITOR | SMITHKLINE BECKMAN CORPORATION (US) | 1988-03-01 | — | — | US | disclosed |
| EP-0190817-A1 | Dopamine-beta-hydroxylase inhibitors | SMITHKLINE BEECHAM CORPORATION (US) | 1986-08-13 | — | — | EP | disclosed |