Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NSD2 | O96028 | 4/20 | 0.69 |
| ▸ | NSD3 | Q9BZ95 | 1/20 | 0.54 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.52 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.52 |
| ▸ | DPP4 | P27487 | 1/20 | 0.49 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.49 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.47 |
| ▸ | AGER | Q15109 | 3/20 | 0.46 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.44 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
| ▸ | GCGR | P47871 | 1/20 | 0.42 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1033157 | 0.86 | NSD2 (0.64) | NSD2NSD3SLC6A2SLC6A4DPP4 | |
| SCHEMBL14264085 | 0.85 | NSD2 (0.61) | NSD2NSD3SLC6A2SLC6A4DPP4 | |
| SCHEMBL2233154 | 0.77 | AGER (0.58) | NSD2SLC6A2SLC6A4AGERMTNR1A | |
| SCHEMBL2233149 | 0.77 | AGER (0.58) | NSD2SLC6A2SLC6A4AGERMTNR1A | |
| SCHEMBL8267199 | 0.76 | NSD2 (0.51) | NSD2NSD3SLC6A2SLC6A4DPP4 | |
| SCHEMBL14264105 | 0.74 | NSD2 (0.48) | NSD2NSD3SLC6A2SLC6A4DPP4 | |
| SCHEMBL4660330 | 0.74 | NSD2 (0.52) | NSD2SLC6A2SLC6A4DPP4MAPKAPK2 | |
| SCHEMBL16578992 | 0.74 | EGLN1 (0.50) | NSD2NSD3SLC6A2SLC6A4PDK2 | |
| SCHEMBL4658111 | 0.74 | NSD2 (0.52) | NSD2SLC6A2SLC6A4DPP4MAPKAPK2 | |
| SCHEMBL3811903 | 0.72 | DCUN1D1 (0.58) | SLC6A2SLC6A4AGERMTNR1ACHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112079769-A | Carboxamide compounds for the treatment of metabolic disorders | 里格尔药品股份有限公司 | 2020-12-15 | — | — | CN | disclosed |
| CN-106928211-B | Carboxamide compounds for the treatment of metabolic disorders | 里格尔药品股份有限公司 | 2020-09-08 | — | — | CN | disclosed |
| CN-106928211-A | Benzamide compound for treating dysbolism | 里格尔药品股份有限公司 | 2017-07-07 | — | — | CN | disclosed |
| CN-104016980-B | For treating the benzamide compound of dysbolismus | 里格尔药品股份有限公司 | 2016-12-07 | — | — | CN | disclosed |
| EP-2276761-A1 | CARBOXAMIDE COMPOUNDS FOR THE TREATMENT OF METABOLIC DISORDERS | Rigel Pharmaceuticals, Inc. (US) | 2011-01-26 | — | — | EP | disclosed |
| WO-2009132136-A1 | CARBOXAMIDE COMPOUNDS FOR THE TREATMENT OF METABOLIC DISORDERS | RIGEL PHARMACEUTICALS, INC. (US) | 2009-10-29 | — | — | WO | disclosed |