Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYR | P14679 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | ALPL | P05186 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9306833 | 0.82 | DAO (0.38) | TSHRKDM4EPOLB | |
| SCHEMBL11687448 | 0.80 | KMT2A (0.38) | TSHRHTTKDM4EKMT2A | |
| SCHEMBL28412208 | 0.73 | PSMD14 (0.33) | NPC1RAB9ASMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL9306736 | 0.70 | CA12 (0.40) | NPC1RAB9ASMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL110725 | 0.70 | ALDH1A1 (0.41) | NPC1HTTRAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL9306192 | 0.69 | MAP4K4 (0.41) | NPC1HTTRAB9ASMN1; SMN2KDM4E | |
| SCHEMBL1524362 | 0.68 | ALDH1A1 (0.40) | NPC1HTTRAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL4658430 | 0.68 | TYR (0.54) | TYRTSHRKDM4EMAPTKMT2A | |
| SCHEMBL28485369 | 0.67 | PARP1 (0.41) | TSHRNPC1RAB9ASMN1; SMN2KMT2A | |
| SCHEMBL4156669 | 0.66 | TYR (0.48) | TYRTSHRHTTKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0190817-B1 | DOPAMINE-BETA-HYDROXYLASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1990-09-05 | — | — | EP | disclosed |
| US-4857540-A | 1-SUBSTITUTED-2-MERCAPTO-(OR AMINOMETHYL-)BENZAMIDAZOLE COMPOUNDS | SMITHKLINE BECKMAN CORPORATION (US) | 1989-08-15 | — | — | US | disclosed |
| US-4728741-A | DOPAMINE BETA-HYDROXYLASE INHIBITOR | SMITHKLINE BECKMAN CORPORATION (US) | 1988-03-01 | — | — | US | disclosed |
| EP-0190817-A1 | Dopamine-beta-hydroxylase inhibitors | SMITHKLINE BEECHAM CORPORATION (US) | 1986-08-13 | — | — | EP | disclosed |