Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | MPI | P34949 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11400822 | 0.87 | SMN1; SMN2 (0.39) | SMN1; SMN2LMNACYP19A1EPHX2RPS6KA5 | |
| SCHEMBL29388965 | 0.84 | RPS6KA5 (0.45) | SMN1; SMN2LMNAEPHX2RPS6KA5HSD11B1 | |
| SCHEMBL120643 | 0.84 | RPS6KA5 (0.45) | SMN1; SMN2LMNAEPHX2RPS6KA5HSD11B1 | |
| Hydrochloric Acid SCHEMBL30667166 | 0.83 | RPS6KA5 (0.44) | SMN1; SMN2LMNAEPHX2RPS6KA5TDP1 | |
| SCHEMBL30046969 | 0.82 | SMN1; SMN2 (0.42) | SMN1; SMN2LMNATDP1RAB9AMPI | |
| SCHEMBL4764441 | 0.82 | SMN1; SMN2 (0.42) | SMN1; SMN2LMNATDP1RAB9AMPI | |
| SCHEMBL4679589 | 0.81 | LMNA (0.38) | SMN1; SMN2LMNACYP19A1EPHX2RPS6KA5 | |
| SCHEMBL10354468 | 0.78 | NAPRT (0.39) | CYP19A1EPHX2HSD11B1NFE2L2MAPT | |
| SCHEMBL30919120 | 0.76 | TDP1 (0.37) | SMN1; SMN2LMNACYP19A1EPHX2RPS6KA5 | |
| SCHEMBL802211 | 0.76 | LMNA (0.41) | SMN1; SMN2LMNACYP19A1TDP1MPI |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0110690-B1 | PREPARATION OF (TRIFLUOROMETHYL)PYRIDINES | THE DOW CHEMICAL COMPANY (US) | 1990-09-26 | — | — | EP | disclosed |
| US-4650875-A | CATALYTIC FLUORINATION OF TRICHLOROMETHYL ANALOG | THE DOW CHEMICAL COMPANY (US) | 1987-03-17 | — | — | US | disclosed |
| US-4590279-A | CATALYTIC FLUORINATION OF (TRICHLOROMETHYL)PYRIDINES | THE DOW CHEMICAL COMPANY (US) | 1986-05-20 | — | — | US | disclosed |
| EP-0110690-A1 | Preparation of (trifluoromethyl)pyridines | THE DOW CHEMICAL COMPANY (US) | 1984-06-13 | — | — | EP | disclosed |
| US-4288599-A | VAPOR PHASE HALOGENATION OF B-PICOLINE WITH CHLORINE AND HYDROGEN FLUORIDE | ISHIHARA SANGYO KAISHA LTD. (JP) | 1981-09-08 | — | — | US | disclosed |