SCHEMBL120643

SCHEMBL120643

FC(F)(F)c1cccnc1Cl

nearest known ligand 0.45

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
RPS6KA5 O75582 1/20 0.45
EPHX2 P34913 1/20 0.43
LMNA P02545 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
HSD11B1 P28845 5/20 0.41
PIK3CD O00329 1/20 0.40
TRPV1 Q8NER1 2/20 0.39
NFE2L2 Q16236 2/20 0.37
MEN1 O00255 1/20 0.37
TNF P01375 1/20 0.37
CXCL8 P10145 1/20 0.37
KMT2A Q03164 1/20 0.37
PAX8 Q06710 1/20 0.37
KLF5 Q13887 1/20 0.37
GRM4 Q14833 1/20 0.37
TAAR1 Q96RJ0 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29388965 1.00 RPS6KA5 (0.45) RPS6KA5EPHX2LMNASMN1; SMN2HSD11B1
Hydrochloric Acid SCHEMBL30667166 0.98 RPS6KA5 (0.44) RPS6KA5EPHX2LMNASMN1; SMN2HSD11B1
SCHEMBL11400822 0.84 SMN1; SMN2 (0.39) RPS6KA5EPHX2LMNASMN1; SMN2HSD11B1
SCHEMBL10354553 0.84 SMN1; SMN2 (0.39) RPS6KA5EPHX2LMNASMN1; SMN2HSD11B1
Formic Acid Methyl Ester SCHEMBL28089168 0.84 NFE2L2 (0.41) RPS6KA5LMNASMN1; SMN2HSD11B1TRPV1
SCHEMBL4679589 0.83 LMNA (0.38) RPS6KA5EPHX2LMNASMN1; SMN2HSD11B1
SCHEMBL30046969 0.79 SMN1; SMN2 (0.42) LMNASMN1; SMN2NFE2L2
SCHEMBL4764441 0.79 SMN1; SMN2 (0.42) LMNASMN1; SMN2NFE2L2
SCHEMBL30919120 0.78 TDP1 (0.37) RPS6KA5EPHX2LMNASMN1; SMN2HSD11B1
SCHEMBL802211 0.77 LMNA (0.41) LMNASMN1; SMN2NFE2L2KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1238 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-224252748-U 2-Amino-3-trifluoromethyl pyridine apparatus for producing 山东汇盟生物科技股份有限公司 2026-05-19 CN claimed
CN-119708067-A Carbazolyl-containing C≡N cyclometalated platinum (II) complex and preparation method and application thereof 新疆大学 2025-03-28 CN claimed
CN-114292227-B Method for preparing 2-chloro-3-trifluoromethyl pyridine 大连九信精细化工有限公司 2024-12-03 CN claimed
CN-118284105-A Composite material, preparation method thereof, light-emitting device and display device TCL科技集团股份有限公司 2024-07-02 CN claimed
CN-117327053-A Preparation method of PKC inhibitor darovasertib 云南万宏医药科技有限公司 2024-01-02 CN claimed
CN-115784977-A Synthesis process of 2-chloro-3-trifluoromethylpyridine 淄博新农基作物科学有限公司 2023-03-14 CN claimed
WO-2022130403-A1 NEW QUATERNARY AMMONIUM SALTS FOR TRIFLUOROMETHYLATION AND PROCESS FOR THE PREPARATION THEREOF COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) 2022-06-23 WO claimed
CN-114292227-A Method for preparing 2-chloro-3-trifluoromethylpyridine 大连九信精细化工有限公司 2022-04-08 CN claimed
EP-3608310-B1 METHOD FOR SEPARATING AND PURIFYING 2-CHLORO-3-TRIFLUOROMETHYLPYRIDINE ISHIHARA SANGYO KAISHA (JP) 2021-12-08 EP claimed
CN-113717095-A Method for preparing 2-chloro-3-trifluoromethylpyridine and 2-chloro-5-trifluoromethylpyridine 山东汇盟生物科技股份有限公司 2021-11-30 CN claimed
EP-0092117-B1 PROCESS FOR PRODUCING CHLORONICOTINIC ACID COMPOUNDS ISHIHARA SANGYO KAISHA, LTD. (JP) 1987-07-15 EP claimed
EP-0078410-B1 PROCESS FOR PRODUCING 3-CHLORO-5-TRIFLUOROMETHYLPYRIDINES ISHIHARA SANGYO KAISHA, LTD. (JP) 1987-05-27 EP claimed
US-4504665-A Process for producing chloronicotinic acid compounds ISHIHARA SANGYO KAISHA LTD. (JP) 1985-03-12 US claimed
US-4490534-A CHLORINATION IN VAPOR PHASE, PRESENCE OF CATALYST ISHIHARA SANGYO KAISHA LTD. (JP) 1984-12-25 US claimed
US-4417055-A Process for producing a β-trifluoromethylpyridine ISHIHARA SANGYO KAISHA LTD. (JP) 1983-11-22 US claimed
EP-0092117-A1 Process for producing chloronicotinic acid compounds ISHIHARA SANGYO KAISHA, LTD. (JP) 1983-10-26 EP claimed
EP-0031218-B1 A 2-AMINO-TRIFLUOROMETHYL-HALOGENOPYRIDINE COMPOUND AND A PROCESS FOR PRODUCING THE SAME ISHIHARA SANGYO KAISHA LTD. (JP) 1983-05-11 EP claimed
EP-0078410-A2 Process for producing 3-chloro-5-trifluoromethylpyridines ISHIHARA SANGYO KAISHA, LTD. (JP) 1983-05-11 EP claimed
US-4288599-A VAPOR PHASE HALOGENATION OF B-PICOLINE WITH CHLORINE AND HYDROGEN FLUORIDE ISHIHARA SANGYO KAISHA LTD. (JP) 1981-09-08 US claimed
US-4266064-A CATALYTIC FLUORINATION IN A VAPOR PHASE ISHIHARA SANGYO KAISHA LTD. (JP) 1981-05-05 US claimed