Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.85 |
| ▸ | HTR1A | P08908 | 2/20 | 0.85 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.85 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.85 |
| ▸ | MAPT | P10636 | 1/20 | 0.85 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.85 |
| ▸ | DRD2 | P14416 | 1/20 | 0.85 |
| ▸ | TSHR | P16473 | 1/20 | 0.85 |
| ▸ | DRD4 | P21917 | 1/20 | 0.85 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.85 |
| ▸ | DRD3 | P35462 | 1/20 | 0.85 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.67 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.67 |
| ▸ | APEX1 | P27695 | 1/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Roxindole SCHEMBL5605611 | 0.92 | TDP1 (1.00) | TDP1HTR1ACYP1A2CYP3A4MAPT | |
| Roxindole SCHEMBL49673 | 0.92 | TDP1 (1.00) | TDP1HTR1ACYP1A2CYP3A4MAPT | |
| Roxindole SCHEMBL5453647 | 0.91 | TDP1 (0.98) | TDP1HTR1ACYP1A2CYP3A4MAPT | |
| SCHEMBL9581698 | 0.88 | TDP1 (0.69) | TDP1HTR1ACYP1A2CYP3A4MAPT | |
| SCHEMBL13532828 | 0.87 | TDP1 (0.74) | TDP1HTR1ACYP1A2CYP3A4MAPT | |
| SCHEMBL9581566 | 0.87 | TDP1 (0.84) | TDP1HTR1ACYP1A2CYP3A4MAPT | |
| SCHEMBL13532826 | 0.87 | HTR1A (0.74) | TDP1HTR1ACYP1A2CYP3A4MAPT | |
| SCHEMBL13532823 | 0.87 | HTR1A (0.74) | TDP1HTR1ACYP1A2CYP3A4MAPT | |
| SCHEMBL13532829 | 0.87 | TDP1 (0.74) | TDP1HTR1ACYP1A2CYP3A4MAPT | |
| Roxindole SCHEMBL29489916 | 0.86 | TDP1 (0.88) | TDP1HTR1ACYP1A2CYP3A4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100009983-A1 | 5 HT RECEPTOR MEDIATED NEUROGENESIS | BRAINCELLS, INC. (US) | 2010-01-14 | — | — | US | disclosed |
| EP-0166183-B1 | USE OF HYDROXYINDOLE DERIVATIVES FOR THE MANUFACTURE OF A MEDICAMENT FOR LOWERING THE BLOOD PRESSURE | MERCK PATENT GmbH (DE) | 1990-10-03 | — | — | EP | disclosed |
| EP-0166183-A2 | Use of hydroxyindole derivatives for the manufacture of a medicament for lowering the blood pressure | MERCK PATENT GmbH (DE) | 1986-01-02 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100009983-A1 | 5 HT RECEPTOR MEDIATED NEUROGENESIS | HTR6, GAP43, HTR5A | TDP1 1815/4885HTR1A 7/4885CYP1A2 4647/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.