Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | TSHR | P16473 | 3/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.43 |
| ▸ | RECQL | P46063 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | CEL | P19835 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10357785 | 0.83 | CYP2D6 (0.40) | TSHRCYP1A2CYP2C9CYP2D6CYP2C19 | |
| SCHEMBL10357751 | 0.83 | TSHR (0.40) | TSHRCYP2C9CYP2D6HTTCEL | |
| SCHEMBL12071322 | 0.81 | CYP2D6 (0.41) | TSHRHSD17B10CYP1A2CYP2C9CYP2D6 | |
| SCHEMBL14682856 | 0.76 | CYP1A2 (0.50) | HSP90AA1CYP3A4ALDH1A1TSHRHSD17B10 | |
| SCHEMBL15535482 | 0.76 | PABPC1 (0.58) | HSP90AA1CYP3A4ALDH1A1TSHRCYP1A2 | |
| SCHEMBL14702952 | 0.76 | CYP1A2 (0.50) | HSP90AA1CYP3A4ALDH1A1TSHRHSD17B10 | |
| SCHEMBL16077847 | 0.76 | CYP1A2 (0.50) | HSP90AA1CYP3A4ALDH1A1TSHRHSD17B10 | |
| SCHEMBL11591649 | 0.73 | CHEK1 (0.56) | CYP3A4ALDH1A1TSHRHSD17B10CYP1A2 | |
| SCHEMBL11589745 | 0.72 | CYP2D6 (0.49) | HSP90AA1CYP3A4ALDH1A1TSHRHSD17B10 | |
| SCHEMBL11592409 | 0.71 | CYP2D6 (0.55) | HSP90AA1CYP3A4ALDH1A1TSHRHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0216127-B1 | 6-PHENOXYMETHYL-4-HYDROXYTETRAHYDROPYRAN-2-ONES, PROCESS FOR THEIR PREPARATION, THEIR USE AS MEDICINES, PHARMACEUTICAL COMPOSITIONS AND INTERMEDIATES | HOECHST AKTIENGESELLSCHAFT (DE) | 1990-09-26 | — | — | EP | disclosed |
| EP-0216127-A2 | 6-Phenoxymethyl-4-hydroxytetrahydropyran-2-ones, process for their preparation, their use as medicines, pharmaceutical compositions and intermediates | HOECHST AKTIENGESELLSCHAFT (DE) | 1987-04-01 | — | — | EP | disclosed |