Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CEL | P19835 | 1/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.36 |
| ▸ | FYN | P06241 | 1/20 | 0.36 |
| ▸ | RET | P07949 | 1/20 | 0.36 |
| ▸ | MET | P08581 | 1/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.36 |
| ▸ | LTK | P29376 | 1/20 | 0.36 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.36 |
| ▸ | FLT3 | P36888 | 1/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.36 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.36 |
| ▸ | CDK8 | P49336 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10356888 | 0.83 | CYP1A2 (0.42) | TSHRCYP2D6CYP2C9CELNPC1 | |
| SCHEMBL10356919 | 0.83 | HSP90AA1 (0.44) | TSHRCYP2D6CYP2C9CELCHEK1 | |
| SCHEMBL10357785 | 0.77 | CYP2D6 (0.40) | TSHRCYP2D6CYP2C9CELFEN1 | |
| SCHEMBL11686137 | 0.76 | CHEK1 (0.55) | TSHRCYP2D6CYP2C9CHEK1NTRK1 | |
| SCHEMBL69852 | 0.73 | HSPA5 (0.53) | TSHRCYP2D6CYP2C9FYNNPC1 | |
| SCHEMBL27679384 | 0.71 | KDM4E (0.44) | TSHRCYP2D6CYP2C9CELNPC1 | |
| SCHEMBL4444016 | 0.71 | SHBG (0.44) | TSHRCYP2C9FYNNPC1RAB9A | |
| SCHEMBL17748789 | 0.70 | CEL (0.44) | TSHRCELNPC1RAB9AGAA | |
| SCHEMBL31413167 | 0.70 | CEL (0.44) | TSHRCELNPC1RAB9AGAA | |
| SCHEMBL31545420 | 0.70 | NPC1 (0.43) | NPC1RAB9AGAAKMT2APKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0216127-B1 | 6-PHENOXYMETHYL-4-HYDROXYTETRAHYDROPYRAN-2-ONES, PROCESS FOR THEIR PREPARATION, THEIR USE AS MEDICINES, PHARMACEUTICAL COMPOSITIONS AND INTERMEDIATES | HOECHST AKTIENGESELLSCHAFT (DE) | 1990-09-26 | — | — | EP | disclosed |
| EP-0216127-A2 | 6-Phenoxymethyl-4-hydroxytetrahydropyran-2-ones, process for their preparation, their use as medicines, pharmaceutical compositions and intermediates | HOECHST AKTIENGESELLSCHAFT (DE) | 1987-04-01 | — | — | EP | disclosed |