Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 3/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | CEL | P19835 | 1/20 | 0.39 |
| ▸ | BCL2 | P10415 | 1/20 | 0.38 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
| ▸ | BCL2A1 | Q16548 | 1/20 | 0.38 |
| ▸ | F2 | P00734 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.35 |
| ▸ | FEN1 | P39748 | 1/20 | 0.33 |
| ▸ | RARB | P10826 | 1/20 | 0.33 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10356888 | 0.83 | CYP1A2 (0.42) | CYP2D6CYP2C9CYP1A2CYP2C19CEL | |
| SCHEMBL10356919 | 0.83 | HSP90AA1 (0.44) | CYP2D6CYP2C9CYP1A2CYP2C19CEL | |
| SCHEMBL12071322 | 0.79 | CYP2D6 (0.41) | CYP2D6CYP2C9CYP1A2CYP2C19CEL | |
| SCHEMBL10357751 | 0.77 | TSHR (0.40) | CYP2D6CYP2C9CELBCL2BCL2L1 | |
| SCHEMBL28182371 | 0.74 | MAOA (0.42) | CYP2D6CYP2C9CYP1A2CYP2C19BCL2 | |
| SCHEMBL67802 | 0.73 | CYP2C9 (0.53) | CYP2D6CYP2C9CYP1A2CYP2C19MAPT | |
| SCHEMBL13888157 | 0.71 | CYP2C9 (0.43) | CYP2D6CYP2C9CYP1A2CYP2C19MAPT | |
| SCHEMBL23201145 | 0.70 | CYP2C9 (0.39) | CYP2D6CYP2C9CYP1A2CYP2C19MAPT | |
| Hydrochloric Acid SCHEMBL30387703 | 0.68 | CYP2C9 (0.38) | CYP2D6CYP2C9CYP1A2CYP2C19MAPT | |
| SCHEMBL4473714 | 0.67 | GRN (0.40) | CELMAPTL3MBTL1KCNH2EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0216127-B1 | 6-PHENOXYMETHYL-4-HYDROXYTETRAHYDROPYRAN-2-ONES, PROCESS FOR THEIR PREPARATION, THEIR USE AS MEDICINES, PHARMACEUTICAL COMPOSITIONS AND INTERMEDIATES | HOECHST AKTIENGESELLSCHAFT (DE) | 1990-09-26 | — | — | EP | disclosed |
| EP-0216127-A2 | 6-Phenoxymethyl-4-hydroxytetrahydropyran-2-ones, process for their preparation, their use as medicines, pharmaceutical compositions and intermediates | HOECHST AKTIENGESELLSCHAFT (DE) | 1987-04-01 | — | — | EP | disclosed |