Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 10/20 | 0.65 |
| ▸ | NPC1 | O15118 | 9/20 | 0.65 |
| ▸ | MAPT | P10636 | 7/20 | 0.65 |
| ▸ | ALOX15 | P16050 | 5/20 | 0.65 |
| ▸ | HPGD | P15428 | 4/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.65 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.65 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.65 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.56 |
| ▸ | MEN1 | O00255 | 7/20 | 0.56 |
| ▸ | RAF1 | P04049 | 4/20 | 0.56 |
| ▸ | CASP3 | P42574 | 3/20 | 0.55 |
| ▸ | SENP8 | Q96LD8 | 3/20 | 0.55 |
| ▸ | SENP7 | Q9BQF6 | 3/20 | 0.55 |
| ▸ | SENP6 | Q9GZR1 | 3/20 | 0.55 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.55 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.55 |
| ▸ | RELA | Q04206 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17279957 | 0.82 | PRKD1 (0.67) | RAB9ANPC1MAPTSMN1; SMN2PRKD1 | |
| SCHEMBL25438397 | 0.81 | PRKD1 (0.69) | RAB9ANPC1MAPTSMN1; SMN2PRKD1 | |
| SCHEMBL9911652 | 0.79 | RAB9A (0.74) | RAB9ANPC1MAPTALOX15HPGD | |
| SCHEMBL28664306 | 0.78 | FYN (0.56) | RAB9ANPC1MAPTSMN1; SMN2PRKD1 | |
| SCHEMBL1528519 | 0.78 | FYN (0.55) | RAB9ANPC1MAPTALOX15SMN1; SMN2 | |
| SCHEMBL10357497 | 0.78 | KMT2A (0.82) | RAB9ANPC1MAPTALOX15HPGD | |
| SCHEMBL17279945 | 0.77 | PRKD1 (0.64) | RAB9ANPC1MAPTHPGDSMN1; SMN2 | |
| SCHEMBL10358361 | 0.77 | MEN1 (0.77) | RAB9ANPC1MAPTALOX15HPGD | |
| SCHEMBL10358566 | 0.76 | KMT2A (0.76) | RAB9ANPC1MAPTALOX15HPGD | |
| SCHEMBL10358281 | 0.76 | MAPT (0.66) | RAB9ANPC1MAPTALOX15HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120184583-A1 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-07-19 | — | — | US | disclosed |
| US-20120184583-A1 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-07-19 | — | — | US | disclosed |
| US-20100144798-A1 | Modulators of ATP-Binding Cassette Transporters | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-06-10 | — | — | US | disclosed |
| US-20100144798-A1 | Modulators of ATP-Binding Cassette Transporters | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-06-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120184583-A1 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | CFTR, ABCB1, ABCC2 | RAB9A 2303/4885NPC1 30/4885MAPT 4385/4885 |
| US-20100144798-A1 | Modulators of ATP-Binding Cassette Transporters | CFTR, ABCB1, ABCC2 | RAB9A 2303/4885NPC1 30/4885MAPT 4385/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.