Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 6/20 | 0.84 |
| ▸ | HTR2C | P28335 | 6/20 | 0.63 |
| ▸ | HTR2B | P41595 | 4/20 | 0.63 |
| ▸ | DRD2 | P14416 | 3/20 | 0.59 |
| ▸ | DRD3 | P35462 | 3/20 | 0.59 |
| ▸ | HTR2A | P28223 | 2/20 | 0.59 |
| ▸ | PNMT | P11086 | 3/20 | 0.57 |
| ▸ | MLNR | O43193 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | BRD4 | O60885 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7452220 | 0.94 | HTR6 (0.84) | HTR6HTR2CHTR2BDRD2DRD3 | |
| Hydrochloric Acid SCHEMBL10563577 | 0.93 | HTR6 (0.82) | HTR6HTR2CHTR2BDRD2DRD3 | |
| SCHEMBL5781306 | 0.92 | HTR6 (1.00) | HTR6HTR2CHTR2BDRD2DRD3 | |
| SCHEMBL6149579 | 0.86 | LMNA (0.69) | HTR6HTR2CHTR2BDRD2DRD3 | |
| SCHEMBL13757776 | 0.86 | PNMT (0.76) | HTR6HTR2CHTR2BDRD2DRD3 | |
| SCHEMBL9959631 | 0.86 | HTR6 (0.63) | HTR6HTR2CHTR2BDRD2DRD3 | |
| Hydrochloric Acid SCHEMBL9958844 | 0.85 | PNMT (0.74) | HTR6HTR2CHTR2BDRD2DRD3 | |
| Hydrochloric Acid SCHEMBL3144025 | 0.85 | HTR6 (0.62) | HTR6HTR2CHTR2BDRD2DRD3 | |
| SCHEMBL10239977 | 0.85 | HTR6 (0.62) | HTR6HTR2CHTR2BDRD2DRD3 | |
| Hydrochloric Acid SCHEMBL3148318 | 0.84 | HTR6 (0.60) | HTR6HTR2CHTR2BDRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0266949-B1 | TETRAHYDROISOQUINOLIN-2-YL DERIVATIVES OF CARBOXYLIC ACIDS AS THROMBOXANE A2 ANTAGONISTS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1990-11-28 | — | — | EP | disclosed |
| US-4812573-A | ARYLSULFONAMIDE SUBSTITUTED TETRAHYDROISOQUINOLINYLALKANOIC ACIDS AS THROMBOXANE A2 ANTAGONISTS | SMITHKLINE & FRENCH LABORATORIES, LTD. (GB) | 1989-03-14 | — | — | US | disclosed |
| EP-0266949-A1 | Tetrahydroisoquinolin-2-yl derivatives of carboxylic acids as thromboxane A2 antagonists | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1988-05-11 | — | — | EP | disclosed |
| WO-1988003137-A1 | TETRAHYDROISOQUINOLIN-2-YL DERIVATIVES OF CARBOXYLIC ACIDS AS THROMBOXANE A2 ANTAGONISTS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1988-05-05 | — | — | WO | disclosed |