Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | PLA2G4B | P0C869 | 6/20 | 0.44 |
| ▸ | RARB | P10826 | 5/20 | 0.44 |
| ▸ | RARA | P10276 | 1/20 | 0.44 |
| ▸ | PTPN11 | Q06124 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10361725 | 0.81 | ALDH1A1 (0.47) | TSHRKDM4EALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL7215515 | 0.80 | CA12 (0.51) | — | |
| SCHEMBL7218211 | 0.79 | CA12 (0.53) | — | |
| SCHEMBL10362787 | 0.78 | PTPN11 (0.50) | RARBRARAPTPN11 | |
| SCHEMBL7217983 | 0.76 | L3MBTL1 (0.53) | SMN1; SMN2 | |
| SCHEMBL10803195 | 0.75 | PTPN11 (0.45) | TP53TSHRPLA2G4BPTPN11ALDH1A1 | |
| SCHEMBL10361694 | 0.75 | ALDH1A1 (0.42) | TSHRKDM4EALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL10362996 | 0.72 | ALDH1A1 (0.42) | KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL21543820 | 0.72 | PTPN11 (0.62) | TP53TSHRPLA2G4BRARBRARA | |
| SCHEMBL6297038 | 0.72 | PPARD (0.57) | TP53TSHRRARBRARAPTPN11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0157346-B1 | QUINOLIZINONE COMPOUND, PROCESSES FOR PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1990-01-31 | — | — | EP | disclosed |
| US-4698349-A | Quinolizinone compounds, and pharmaceutical composition comprising the same, useful as anti-ulcerative and anti-allergic agents | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1987-10-06 | — | — | US | disclosed |
| US-4650804-A | TETRAZOLYLCARBAMOYL DERIVATIVE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1987-03-17 | — | — | US | disclosed |
| EP-0157346-A2 | Quinolizinone compound, processes for preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1985-10-09 | — | — | EP | disclosed |