Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | TGM2 | P21980 | 1/20 | 0.44 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.43 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.43 |
| ▸ | ITGB3 | P05106 | 4/20 | 0.42 |
| ▸ | ITGA2B | P08514 | 4/20 | 0.42 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | TDO2 | P48775 | 1/20 | 0.40 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.40 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7222273 | 0.88 | L3MBTL1 (0.53) | L3MBTL1MAPTHTTLMNASMN1; SMN2 | |
| SCHEMBL7380531 | 0.85 | L3MBTL1 (0.44) | L3MBTL1MAPTHTTLMNASMN1; SMN2 | |
| SCHEMBL7378110 | 0.81 | L3MBTL1 (0.45) | L3MBTL1MAPTHTTITGB3ITGA2B | |
| SCHEMBL7218211 | 0.78 | CA12 (0.53) | ITGB3ITGA2B | |
| SCHEMBL10361669 | 0.76 | TP53 (0.46) | SMN1; SMN2 | |
| SCHEMBL3811564 | 0.73 | L3MBTL1 (0.80) | L3MBTL1MAPTHTTLMNASMN1; SMN2 | |
| SCHEMBL20500014 | 0.73 | L3MBTL1 (0.74) | L3MBTL1MAPTHTTLMNASMN1; SMN2 | |
| SCHEMBL17536575 | 0.72 | L3MBTL1 (0.59) | L3MBTL1MAPTHTTLMNASMN1; SMN2 | |
| SCHEMBL7222259 | 0.72 | CA12 (0.47) | MAPTITGB3ITGA2BGAA | |
| SCHEMBL3167269 | 0.72 | L3MBTL1 (0.65) | L3MBTL1MAPTHTTLMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6630488-B1 | Quinolizinones as integrin inhibitors | BIOCHEM PHARMA, INC. (CA) | 2003-10-07 | — | — | US | disclosed |
| EP-1115724-A1 | QUINOLIZINONES AS INTEGRIN INHIBITORS | Shire Biochem Inc. (CA) | 2001-07-18 | — | — | EP | disclosed |
| WO-2000017197-A1 | QUINOLIZINONES AS INTEGRIN INHIBITORS | BIOCHEM PHARMA INC. (US) | 2000-03-30 | — | — | WO | disclosed |