Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 4/20 | 0.54 |
| ▸ | CA1 | P00915 | 4/20 | 0.54 |
| ▸ | CA2 | P00918 | 4/20 | 0.54 |
| ▸ | CA7 | P43166 | 4/20 | 0.54 |
| ▸ | CA9 | Q16790 | 4/20 | 0.54 |
| ▸ | CA14 | Q9ULX7 | 4/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.51 |
| ▸ | HPGD | P15428 | 5/20 | 0.51 |
| ▸ | GAA | P10253 | 5/20 | 0.51 |
| ▸ | GLA | P06280 | 4/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | MIF | P14174 | 1/20 | 0.44 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10362962 | 0.87 | KDM4E (0.62) | CA12CA1CA2CA7CA9 | |
| SCHEMBL6754552 | 0.86 | KDM4E (0.51) | CA12CA1CA2CA7CA9 | |
| SCHEMBL25223019 | 0.85 | KDM4E (0.50) | CA12CA1CA2CA7CA9 | |
| SCHEMBL6755336 | 0.85 | KDM4E (0.50) | CA12CA1CA2CA7CA9 | |
| SCHEMBL8565982 | 0.81 | KDM4E (0.46) | CA12CA1CA2CA7CA9 | |
| SCHEMBL4616746 | 0.80 | KDM4E (0.64) | KDM4EALDH1A1HPGDGAAGLA | |
| SCHEMBL7222086 | 0.80 | CA12 (0.53) | CA12CA1CA2CA7CA9 | |
| SCHEMBL6752153 | 0.80 | KDM4E (0.46) | CA12CA1CA2CA7CA9 | |
| SCHEMBL6754479 | 0.79 | ALDH1A1 (0.45) | CA12CA2CA7CA9CA14 | |
| SCHEMBL8136267 | 0.78 | KDM4E (0.45) | KDM4EALDH1A1HPGDGAAGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0157346-B1 | QUINOLIZINONE COMPOUND, PROCESSES FOR PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1990-01-31 | — | — | EP | disclosed |
| US-4698349-A | Quinolizinone compounds, and pharmaceutical composition comprising the same, useful as anti-ulcerative and anti-allergic agents | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1987-10-06 | — | — | US | disclosed |
| US-4650804-A | TETRAZOLYLCARBAMOYL DERIVATIVE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1987-03-17 | — | — | US | disclosed |
| EP-0157346-A2 | Quinolizinone compound, processes for preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1985-10-09 | — | — | EP | disclosed |