Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.49 |
| ▸ | DRD4 | P21917 | 1/20 | 0.49 |
| ▸ | DRD3 | P35462 | 1/20 | 0.49 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.49 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | USP30 | Q70CQ3 | 8/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10985997 | 0.82 | DRD2 (0.55) | DRD2DRD4DRD3GRM2HTR1A | |
| SCHEMBL10991961 | 0.81 | DRD2 (0.52) | DRD2DRD4DRD3GRM2HTR1A | |
| SCHEMBL1840347 | 0.81 | DRD2 (0.58) | DRD2DRD4DRD3GRM2HTR1A | |
| Bromide SCHEMBL10365464 | 0.79 | DRD2 (0.57) | DRD2DRD4DRD3GRM2HTR1A | |
| Hydrochloric Acid SCHEMBL1836699 | 0.79 | DRD2 (0.57) | DRD2DRD4DRD3GRM2HTR1A | |
| SCHEMBL10364952 | 0.76 | DRD2 (0.57) | DRD2DRD4DRD3GRM2HTR1A | |
| SCHEMBL2204018 | 0.75 | DRD2 (0.46) | DRD2DRD4DRD3GRM2HTR1A | |
| SCHEMBL10987775 | 0.75 | GRM4 (0.55) | DRD2DRD4DRD3GRM2HTR1A | |
| Bromide SCHEMBL10365633 | 0.75 | DRD2 (0.56) | DRD2DRD4DRD3GRM2HTR1A | |
| SCHEMBL10505910 | 0.75 | DRD2 (0.47) | DRD2DRD4DRD3GRM2HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4458076-A | ANALGESICS, ANTIPSYCHOTICS | HOECHST-ROUSSEL PHARMACEUTICALS (US) | 1984-07-03 | — | — | US | claimed |
| EP-0127167-B1 | 3-(4-PIPERIDINYL)-1,2-BENZISOTHIAZOLES AND DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1990-04-04 | — | — | EP | disclosed |
| EP-0159666-B1 | ANTIHYPERTENSIVE 1,2-BENZISOTHIAZOLE PIPERIDINES, A METHOD FOR SYNTHESIZING THE SAME AND THEIR USE AS MEDICAMENTS | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1989-06-14 | — | — | EP | disclosed |
| US-4558056-A | PSYCHOLOGICAL DISORDERS | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1985-12-10 | — | — | US | disclosed |
| EP-0159666-A2 | Antihypertensive 1,2-Benzisothiazole Piperidines, a method for synthesizing the same and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1985-10-30 | — | — | EP | disclosed |
| US-4528292-A | Antihypertensive 1,2-benzisothiazole piperidines | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1985-07-09 | — | — | US | disclosed |
| US-4524074-A | TREATMENT OF PSYCHOSES | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1985-06-18 | — | — | US | disclosed |
| EP-0127167-A2 | 3-(4-Piperidinyl)-1,2-benzisothiazoles and derivatives, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1984-12-05 | — | — | EP | disclosed |
| US-4458076-A | ANALGESICS, ANTIPSYCHOTICS | HOECHST-ROUSSEL PHARMACEUTICALS (US) | 1984-07-03 | — | — | US | disclosed |