Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCAT2 | O15382 | 1/20 | 0.53 |
| ▸ | WDR5 | P61964 | 1/20 | 0.47 |
| ▸ | F9 | P00740 | 1/20 | 0.44 |
| ▸ | PLAU | P00749 | 7/20 | 0.43 |
| ▸ | PLAT | P00750 | 6/20 | 0.43 |
| ▸ | F7 | P08709 | 5/20 | 0.43 |
| ▸ | F2 | P00734 | 4/20 | 0.43 |
| ▸ | F10 | P00742 | 4/20 | 0.43 |
| ▸ | F12 | P00748 | 1/20 | 0.43 |
| ▸ | F3 | P13726 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | PRSS1 | P07477 | 7/20 | 0.42 |
| ▸ | PRSS2 | P07478 | 7/20 | 0.42 |
| ▸ | PRSS3 | P35030 | 7/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | KLKB1 | P03952 | 5/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL32689453 | 0.91 | BCAT2 (0.63) | BCAT2WDR5F9PLAUPLAT | |
| SCHEMBL1034554 | 0.91 | BCAT2 (0.63) | BCAT2WDR5F9PLAUPLAT | |
| Ammonia Solution, Strong SCHEMBL29131061 | 0.89 | BCAT2 (0.61) | BCAT2WDR5F9PLAUPLAT | |
| Hydrochloric Acid SCHEMBL27450056 | 0.89 | BCAT2 (0.61) | BCAT2WDR5F9PLAUPLAT | |
| Hydrochloric Acid SCHEMBL31621742 | 0.89 | BCAT2 (0.61) | BCAT2WDR5F9PLAUPLAT | |
| SCHEMBL752611 | 0.87 | F2 (0.48) | BCAT2WDR5F9PLAUPLAT | |
| SCHEMBL7151686 | 0.85 | BCAT2 (0.55) | BCAT2WDR5F9PLAUPLAT | |
| Hydrochloric Acid SCHEMBL6341904 | 0.84 | BLM (0.50) | BCAT2WDR5F9PLAUPLAT | |
| SCHEMBL28513902 | 0.80 | BCAT2 (0.50) | BCAT2WDR5F9PLAUPLAT | |
| SCHEMBL6832583 | 0.80 | BCAT2 (0.50) | BCAT2WDR5F9PLAUPLAT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8268845-B2 | Tetrahydro- and dihydroquinazolinones | MERCK PATENT GMBH (DE) | 2012-09-18 | — | — | US | disclosed |
| US-20110195965-A1 | TETRAHYDRO- AND DIHYDROQUINAZOLINONES | FINSINGER DIRK | 2011-08-11 | — | — | US | disclosed |
| EP-1856061-B1 | TETRAHYDRO- AND DIHYDROQUINAZOLINONES | MERCK PATENT GMBH (DE) | 2011-01-26 | — | — | EP | disclosed |
| US-20090318444-A1 | TETRAHYDRO- AND DIHYDROQUINAZOLINONES | MERCK PATENT GMBH (DE) | 2009-12-24 | — | — | US | disclosed |
| EP-1856061-A1 | TETRAHYDRO- AND DIHYDROQUINAZOLINONES | Merck Patent GmbH (DE) | 2007-11-21 | — | — | EP | disclosed |
| WO-2006094604-A1 | TETRAHYDRO- AND DIHYDROQUINAZOLINONES | MERCK PATENT GMBH (DE) | 2006-09-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110195965-A1 | TETRAHYDRO- AND DIHYDROQUINAZOLINONES | CSNK1A1, MAP3K19, CSNK1E | BCAT2 1374/4885WDR5 3357/4885F9 3592/4885 |
| US-20090318444-A1 | TETRAHYDRO- AND DIHYDROQUINAZOLINONES | CSNK1A1, MAP3K19, DMPK | BCAT2 1577/4885WDR5 3372/4885F9 3680/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.