Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.71 |
| ▸ | LMNA | P02545 | 3/20 | 0.71 |
| ▸ | GAA | P10253 | 3/20 | 0.71 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.63 |
| ▸ | HTT | P42858 | 2/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.60 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | CASP1 | P29466 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.51 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | ABL1 | P00519 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5138088 | 0.88 | MAPT (0.56) | MAPTLMNAGAAKDM4EALDH1A1 | |
| SCHEMBL6225314 | 0.86 | MAPT (0.53) | MAPTLMNAGAAKDM4EALDH1A1 | |
| SCHEMBL15127501 | 0.84 | MAPT (0.79) | MAPTLMNAGAAKDM4EALDH1A1 | |
| SCHEMBL5542809 | 0.83 | MAPT (1.00) | MAPTLMNAGAAKDM4EALDH1A1 | |
| SCHEMBL5542804 | 0.83 | MAPT (0.77) | MAPTLMNAGAAKDM4EALDH1A1 | |
| SCHEMBL31050602 | 0.83 | ALDH1A1 (0.53) | MAPTLMNAGAAKDM4EALDH1A1 | |
| SCHEMBL23201166 | 0.82 | CA1 (0.58) | MAPTLMNAGAAKDM4ESMN1; SMN2 | |
| SCHEMBL2581059 | 0.82 | MAPT (0.75) | MAPTLMNAGAAKDM4EALDH1A1 | |
| SCHEMBL27610366 | 0.81 | MAPT (0.74) | MAPTLMNAGAAKDM4EALDH1A1 | |
| SCHEMBL209802 | 0.81 | MAPT (0.64) | MAPTLMNAALDH1A1SMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0200947-B1 | 1,3-DISUBSTITUTED IMIDAZOLIUM SALTS | F. HOFFMANN-LA ROCHE AG (CH) | 1990-09-12 | — | — | EP | disclosed |
| US-4831151-A | NEMATOCIDES | HOFFMANN-LA ROCHE INC. (US) | 1989-05-16 | — | — | US | disclosed |