Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.46 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.46 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.46 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | NR1D1 | P20393 | 2/20 | 0.44 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.44 |
| ▸ | PIN1 | Q13526 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | CCR6 | P51684 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL10365051 | 0.99 | HTT (0.46) | HTTSMN1; SMN2POLBCYP11B1CYP11B2 | |
| SCHEMBL5038066 | 0.78 | PIN1 (0.37) | SMN1; SMN2POLBALDH1A1CYP19A1PIN1 | |
| SCHEMBL5033869 | 0.77 | PIN1 (0.62) | SMN1; SMN2POLBCYP11B1CYP11B2ALDH1A1 | |
| SCHEMBL10920095 | 0.77 | ALDH1A1 (0.48) | HTTSMN1; SMN2POLBCYP11B1CYP11B2 | |
| SCHEMBL11232440 | 0.76 | CYP11B1 (0.49) | CYP11B1CYP11B2ALDH1A1RAB9AL3MBTL1 | |
| SCHEMBL5547199 | 0.76 | ALDH1A1 (0.40) | POLBCYP11B1CYP11B2ALDH1A1PIN1 | |
| SCHEMBL10365876 | 0.75 | ALDH1A1 (0.44) | HTTSMN1; SMN2POLBCYP11B1CYP11B2 | |
| SCHEMBL487814 | 0.73 | PIN1 (0.39) | HTTSMN1; SMN2ALDH1A1PIN1MAPT | |
| SCHEMBL19072274 | 0.73 | SMN1; SMN2 (0.40) | HTTSMN1; SMN2ALDH1A1PIN1MAPT | |
| SCHEMBL487553 | 0.73 | PIN1 (0.39) | HTTSMN1; SMN2ALDH1A1PIN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0244201-B1 | 3-HYDROXYPYRIDINES | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1990-09-26 | — | — | EP | disclosed |
| US-4863933-A | HISTAMINE H1 ANTAGONISTS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1989-09-05 | — | — | US | disclosed |
| US-4764519-A | ANTIHISTAMINES | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1988-08-16 | — | — | US | disclosed |