Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NCOA1 | Q15788 | 1/20 | 0.52 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 7/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.50 |
| ▸ | MAPT | P10636 | 5/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.48 |
| ▸ | HPGD | P15428 | 5/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | PKM | P14618 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | CASP1 | P29466 | 3/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9751601 | 0.84 | HSD17B10 (0.59) | MEN1KMT2AALDH1A1MAPTHDAC3 | |
| SCHEMBL6421307 | 0.84 | ALDH1A1 (0.54) | MEN1KMT2AALDH1A1MAPTHDAC3 | |
| SCHEMBL7429124 | 0.82 | SMN1; SMN2 (0.53) | MEN1KMT2AALDH1A1MAPTHDAC3 | |
| SCHEMBL28571148 | 0.82 | HSD17B10 (0.55) | MEN1KMT2AALDH1A1MAPTHDAC3 | |
| SCHEMBL1722192 | 0.82 | MEN1 (0.54) | NCOA1NCOA3MEN1KMT2AALDH1A1 | |
| SCHEMBL19630686 | 0.81 | KMT2A (0.58) | MEN1KMT2AALDH1A1MAPTHDAC3 | |
| SCHEMBL25740966 | 0.77 | LMNA (0.54) | KMT2AALDH1A1MAPTHSD17B10HPGD | |
| SCHEMBL1617976 | 0.76 | CYP19A1 (0.49) | KMT2AALDH1A1MAPTPKMSMN1; SMN2 | |
| SCHEMBL7900139 | 0.75 | LMNA (0.79) | NCOA1NCOA3MEN1KMT2AALDH1A1 | |
| SCHEMBL7410135 | 0.75 | ALDH1A1 (0.50) | MEN1KMT2AALDH1A1MAPTHDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0206747-B1 | 1,4-DIHYDROPYRIDINE DERIVATIVES USEFUL IN THE TREATMENT OF CARDIOVASCULAR DISORDERS, AND A PROCESS FOR PRODUCING THE DERIVATIVES | WARNER-LAMBERT COMPANY (US) | 1990-10-31 | — | — | EP | disclosed |
| EP-0206747-A2 | 1,4-Dihydropyridine derivatives useful in the treatment of cardiovascular disorders, and a process for producing the derivatives | WARNER-LAMBERT COMPANY (US) | 1986-12-30 | — | — | EP | disclosed |