Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.50 |
| ▸ | MAPT | P10636 | 6/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.47 |
| ▸ | MEN1 | O00255 | 5/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9751601 | 0.88 | HSD17B10 (0.59) | SMN1; SMN2ALDH1A1MAPTKMT2AMEN1 | |
| SCHEMBL11539971 | 0.87 | SMN1; SMN2 (0.56) | SMN1; SMN2ALDH1A1MAPTKMT2AMEN1 | |
| SCHEMBL1722192 | 0.85 | MEN1 (0.54) | SMN1; SMN2ALDH1A1MAPTKMT2AMEN1 | |
| SCHEMBL28571148 | 0.85 | HSD17B10 (0.55) | SMN1; SMN2ALDH1A1MAPTKMT2AMEN1 | |
| SCHEMBL6421307 | 0.84 | ALDH1A1 (0.54) | SMN1; SMN2ALDH1A1MAPTKMT2AMEN1 | |
| SCHEMBL19630686 | 0.84 | KMT2A (0.58) | ALDH1A1MAPTKMT2AMEN1HDAC3 | |
| SCHEMBL10366553 | 0.82 | NCOA1 (0.52) | SMN1; SMN2ALDH1A1MAPTKMT2AMEN1 | |
| SCHEMBL20661399 | 0.79 | SMN1; SMN2 (0.61) | SMN1; SMN2ALDH1A1MAPTKMT2AMEN1 | |
| SCHEMBL7651344 | 0.78 | HSP90AA1 (0.51) | SMN1; SMN2ALDH1A1MAPTKMT2AMEN1 | |
| SCHEMBL2378422 | 0.77 | SMN1; SMN2 (0.59) | SMN1; SMN2ALDH1A1MAPTKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108264509-B | Substituted benzothieno [2,3-c ] tetrahydropyridine derivatives, preparation method and application thereof | 复旦大学 | 2021-05-04 | — | — | CN | disclosed |
| EP-0375451-A2 | Compounds having a renin-inhibiting activity | BEECHAM GROUP PLC (GB) | 1990-06-27 | — | — | EP | disclosed |
| EP-0350163-A2 | Renin inhibitory peptides | BEECHAM GROUP PLC (GB) | 1990-01-10 | — | — | EP | disclosed |