Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.51 |
| ▸ | MGLL | Q99685 | 1/20 | 0.49 |
| ▸ | HTR2A | P28223 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | HTR7 | P34969 | 1/20 | 0.43 |
| ▸ | HTR6 | P50406 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.42 |
| ▸ | SLC6A1 | P30531 | 1/20 | 0.42 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL10365798 | 0.99 | HSD11B1 (0.50) | HSD11B1MGLLHTR2AKMT2ATDP1 | |
| SCHEMBL10164227 | 0.83 | KMT2A (0.59) | HTR2AKMT2AHTR2C | |
| SCHEMBL10371607 | 0.82 | HSD11B1 (0.48) | HSD11B1MGLLHTR2AKMT2ATDP1 | |
| SCHEMBL10447258 | 0.81 | HTR2A (0.69) | HTR2AHTR2CHTR7HTR6GRM2 | |
| SCHEMBL29591363 | 0.81 | CES2 (0.56) | HSD11B1MGLLKMT2ATDP1CYP2C9 | |
| SCHEMBL718095 | 0.81 | CES2 (0.56) | HSD11B1MGLLKMT2ATDP1CYP2C9 | |
| SCHEMBL6661943 | 0.80 | HSD11B1 (0.55) | HSD11B1MGLLKMT2AHTR7EPHX2 | |
| Hydrochloric Acid SCHEMBL10395819 | 0.79 | HSD11B1 (0.53) | HSD11B1MGLLKMT2AHTR7EPHX2 | |
| SCHEMBL17938078 | 0.79 | HSD11B1 (0.60) | HSD11B1MGLLKMT2ACYP2C9CYP2C19 | |
| SCHEMBL5927208 | 0.79 | KMT2A (0.52) | HSD11B1MGLLKMT2ASLC18A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0127167-B1 | 3-(4-PIPERIDINYL)-1,2-BENZISOTHIAZOLES AND DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1990-04-04 | — | — | EP | disclosed |