Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 8/20 | 0.69 |
| ▸ | HTR2C | P28335 | 3/20 | 0.59 |
| ▸ | HTR7 | P34969 | 3/20 | 0.59 |
| ▸ | HTR6 | P50406 | 3/20 | 0.59 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.58 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10164227 | 0.86 | KMT2A (0.59) | HTR2AHTR2CKDM4ESIGMAR1 | |
| SCHEMBL7839803 | 0.82 | HTR2A (1.00) | HTR2AHTR2CHTR7HTR6OPRM1 | |
| SCHEMBL1582470 | 0.82 | HTR2A (0.87) | HTR2AHTR2CHTR7HTR6KDM4E | |
| Hydrochloric Acid SCHEMBL7828801 | 0.81 | HTR2A (0.97) | HTR2AHTR2CHTR7HTR6OPRM1 | |
| SCHEMBL10366605 | 0.81 | HSD11B1 (0.51) | HTR2AHTR2CHTR7HTR6GRM2 | |
| Hydrochloric Acid SCHEMBL7418228 | 0.81 | HTR2A (0.85) | HTR2AHTR2CHTR7HTR6KDM4E | |
| SCHEMBL27300983 | 0.80 | HTR2A (0.75) | HTR2AHTR2COPRM1KDM4ECYP1A2 | |
| SCHEMBL1519356 | 0.80 | HTR2A (0.75) | HTR2AOPRM1SIGMAR1 | |
| Hydrochloric Acid SCHEMBL10365798 | 0.80 | HSD11B1 (0.50) | HTR2AHTR2CHTR7HTR6KDM4E | |
| SCHEMBL6661943 | 0.79 | HSD11B1 (0.55) | HTR7SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0360275-A2 | Imidazole antiarrhythmics | MERRELL DOW PHARMACEUTICALS INC. (US) | 1990-03-28 | — | — | EP | disclosed |