Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | AIMP2 | Q13155 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 2/20 | 0.40 |
| ▸ | MAOB | P27338 | 6/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.40 |
| ▸ | AOC2 | O75106 | 5/20 | 0.39 |
| ▸ | MAOA | P21397 | 5/20 | 0.39 |
| ▸ | DAO | P14920 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10366357 | 0.86 | HTR1A (0.50) | HRH3HTR1AMAOBSIGMAR1AOC2 | |
| SCHEMBL7086692 | 0.84 | ALDH1A1 (0.46) | HRH3HTR1AMAOBSIGMAR1AOC2 | |
| SCHEMBL28272582 | 0.84 | TP53 (0.44) | HRH3AIMP2HTR1AMAOBSIGMAR1 | |
| SCHEMBL10366765 | 0.77 | HRH3 (0.43) | HRH3HTR1AMAOBSIGMAR1AOC2 | |
| SCHEMBL9935891 | 0.72 | HRH3 (0.49) | HRH3HTR1AMAOBSIGMAR1AOC2 | |
| SCHEMBL6723015 | 0.72 | HRH3 (0.53) | HRH3HTR1AMAOBSIGMAR1AOC2 | |
| SCHEMBL4526675 | 0.72 | HRH3 (0.49) | HRH3HTR1AMAOBSIGMAR1AOC2 | |
| SCHEMBL10736602 | 0.72 | HRH3 (0.49) | HRH3HTR1AMAOBSIGMAR1AOC2 | |
| SCHEMBL718265 | 0.72 | HRH3 (0.49) | HRH3HTR1AMAOBAOC2MAOA | |
| SCHEMBL434338 | 0.72 | HRH3 (0.49) | HRH3MAOBAOC2MAOADAO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0207605-B1 | HYPOGLYCEMIC THIAZOLIDINEDIONES | PFIZER INC. (US) | 1990-02-07 | — | — | EP | disclosed |
| US-4703052-A | Hypoglycemic thiazolidinediones | PFIZER INC. (US) | 1987-10-27 | — | — | US | disclosed |
| EP-0207605-A1 | Hypoglycemic thiazolidinediones | PFIZER INC. (US) | 1987-01-07 | — | — | EP | disclosed |
| WO-1986007056-A1 | HYPOGLYCEMIC THIAZOLIDINEDIONES | PFIZER INC. (US) | 1986-12-04 | — | — | WO | disclosed |