SCHEMBL10366357

SCHEMBL10366357

c1ccc(CC2Cc3ccccc3O2)cc1

nearest known ligand 0.50

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
HTR1A P08908 5/20 0.50
SIGMAR1 Q99720 5/20 0.50
HRH3 Q9Y5N1 1/20 0.47
ADRA2A P08913 1/20 0.46
ADRA2B P18089 1/20 0.46
ADRA2C P18825 1/20 0.46
GRM2 Q14416 1/20 0.41
SLC6A2 P23975 1/20 0.41
SLC6A4 P31645 1/20 0.41
SLC6A3 Q01959 1/20 0.41
AOC2 O75106 5/20 0.40
MAOA P21397 5/20 0.40
MAOB P27338 5/20 0.40
DAO P14920 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28272582 0.86 TP53 (0.44) HTR1ASIGMAR1HRH3ADRA2AADRA2B
SCHEMBL10366708 0.86 HRH3 (0.43) HTR1ASIGMAR1HRH3AOC2MAOA
SCHEMBL7086692 0.86 ALDH1A1 (0.46) HTR1ASIGMAR1HRH3AOC2MAOA
SCHEMBL14435037 0.82 CYP3A4 (0.49) HTR1ASIGMAR1HRH3ADRA2AADRA2B
SCHEMBL9153669 0.82 HTR1A (0.66) HTR1ASIGMAR1ADRA2AADRA2BADRA2C
SCHEMBL9153673 0.82 HTR1A (0.66) HTR1ASIGMAR1ADRA2AADRA2BADRA2C
SCHEMBL10368729 0.80 HRH3 (0.41) HTR1ASIGMAR1HRH3ADRA2AADRA2B
SCHEMBL10750642 0.80 SMN1; SMN2 (0.46) SIGMAR1HRH3
SCHEMBL8035957 0.78 DRD2 (0.53)
SCHEMBL10736602 0.77 HRH3 (0.49) HTR1ASIGMAR1HRH3ADRA2AADRA2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2766120-A1 METHOD FOR CATALYTIC HETEROAROMATIC HYDROGENATION Westfälische Wilhelms-Universität Münster (DE) 2014-08-20 EP disclosed
WO-2013053796-A1 METHOD FOR CATALYTIC HETEROAROMATIC HYDROGENATION Westfälische Wilhelms Universität Münster (DE) 2013-04-18 WO disclosed
WO-2013053796-A1 METHOD FOR CATALYTIC HETEROAROMATIC HYDROGENATION Westfälische Wilhelms Universität Münster (DE) 2013-04-18 WO disclosed
EP-0199235-B1 PHENYLALKYL-2,3-DIHYDROBENZOFURANS AND ANALOGS USEFUL AS ANTI-INFLAMMATORY AGENTS MERCK & CO. INC. (US) 1990-08-08 EP disclosed
CN-1007248-B PROCESS FOR MANUFACTURING OF FLOOD SUGAR REDUCING MEDICINE-THIAZOLIDINEDIONS PFIZER (US) 1990-03-21 CN disclosed
EP-0207605-B1 HYPOGLYCEMIC THIAZOLIDINEDIONES PFIZER INC. (US) 1990-02-07 EP disclosed
US-4775679-A Certain heterocyclic-ethyl-2,3-dihydrobenzofurans useful as anti-inflammatory agents MERCK & CO., INC. (US) 1988-10-04 US disclosed
US-4713393-A TOPICAL TREATMENT OF SKIN DISORDERS MERCK & CO., INC. (US) 1987-12-15 US disclosed
US-4703052-A Hypoglycemic thiazolidinediones PFIZER INC. (US) 1987-10-27 US disclosed
CN-86104075-A Preparation method of hypoglycemic agent-thiazolidinedione 1987-03-11 CN disclosed
EP-0207605-A1 Hypoglycemic thiazolidinediones PFIZER INC. (US) 1987-01-07 EP disclosed
WO-1986007056-A1 HYPOGLYCEMIC THIAZOLIDINEDIONES PFIZER INC. (US) 1986-12-04 WO disclosed