SCHEMBL10366758

SCHEMBL10366758

SCCC/C=C/CCCc1ccccc1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SIGMAR1 Q99720 4/20 0.43
MAOA P21397 1/20 0.43
DHFR P00374 1/20 0.42
MAOB P27338 2/20 0.42
HTR2A P28223 1/20 0.42
IDO1 P14902 2/20 0.41
HDAC3 O15379 1/20 0.41
MAPK1 P28482 1/20 0.41
ADRA1A P35348 1/20 0.41
HDAC4 P56524 1/20 0.41
SLC6A3 Q01959 1/20 0.41
HDAC1 Q13547 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
HDAC7 Q8WUI4 1/20 0.41
HDAC2 Q92769 1/20 0.41
HDAC10 Q969S8 1/20 0.41
HDAC11 Q96DB2 1/20 0.41
HDAC8 Q9BY41 1/20 0.41
HDAC6 Q9UBN7 1/20 0.41
HDAC9 Q9UKV0 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10366759 1.00 SIGMAR1 (0.43) SIGMAR1MAOADHFRMAOBHTR2A
SCHEMBL10367679 0.92 SIGMAR1 (0.43) SIGMAR1MAOADHFRMAOBHTR2A
SCHEMBL10367681 0.92 SIGMAR1 (0.43) SIGMAR1MAOADHFRMAOBHTR2A
SCHEMBL80775 0.82 SIGMAR1 (0.54) SIGMAR1MAOAMAOBHTR2AIDO1
SCHEMBL133186 0.80 MAOA (0.58) SIGMAR1MAOAMAOBHTR2AIDO1
Hydrochloric Acid SCHEMBL11310548 0.79 MAOB (0.45) SIGMAR1MAOAMAOBHTR2AIDO1
SCHEMBL19031837 0.79 EPHX2 (0.49) SIGMAR1ADRA1ASLC6A3SMN1; SMN2
SCHEMBL19031840 0.79 EPHX2 (0.52) SIGMAR1MAOAADRA1ASLC6A3
SCHEMBL16892624 0.79 TDP1 (0.48) SIGMAR1MAOAMAOBHTR2AHDAC3
SCHEMBL16892625 0.79 TDP1 (0.48) SIGMAR1MAOAMAOBHTR2AHDAC3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0164075-B1 7-OXABICYCLOHEPTANE SUBSTITUTED THIO PROSTAGLANDIN ANALOGS E.R. Squibb & Sons, Inc. (US) 1990-09-12 EP disclosed
US-4560698-A ANTIINFLAMMATORY, ANALGESIC, ANTICOAGULANT, BRONCHODILATOR, VASODILATION, ENZYME INHIBITORS E. R. SQUIBB & SONS, INC. (US) 1985-12-24 US disclosed
EP-0164075-A2 7-Oxabicycloheptane substituted thio prostaglandin analogs E.R. Squibb & Sons, Inc. (US) 1985-12-11 EP disclosed