Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | CDK8 | P49336 | 3/20 | 0.47 |
| ▸ | CCNC | P24863 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 3/20 | 0.39 |
| ▸ | TBK1 | Q9UHD2 | 2/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.39 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | PAK4 | O96013 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | PRKACA | P17612 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10364879 | 0.87 | EIF4E (0.41) | SIRT3TDP1CDK8CCNCABL1 | |
| SCHEMBL10367445 | 0.86 | CDK8 (0.44) | SIRT3TDP1CDK8CCNCLMNA | |
| SCHEMBL10367425 | 0.85 | SIRT3 (0.48) | SIRT3TDP1CDK8CCNCLMNA | |
| SCHEMBL10367437 | 0.84 | SIRT3 (0.40) | SIRT3TDP1CDK8CCNCLMNA | |
| SCHEMBL10364884 | 0.83 | ALDH1A1 (0.40) | SIRT3TDP1CDK8CCNCABL1 | |
| SCHEMBL10367006 | 0.83 | SIRT3 (0.39) | SIRT3TDP1CDK8CCNCLMNA | |
| SCHEMBL688062 | 0.79 | CDC7 (0.46) | CDK8CCNCLMNACYP1A2CYP3A4 | |
| SCHEMBL10365276 | 0.73 | TGFBR1 (0.47) | CYP1A2ACVR1MAPT | |
| SCHEMBL10365452 | 0.72 | CYP3A4 (0.38) | LMNACYP1A2CYP3A4CYP2C19LIMK1 | |
| SCHEMBL10365737 | 0.71 | CYP11B1 (0.40) | ABL1PRKCQCYP19A1GPBAR1LATS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0199968-B1 | THIAZOLE DERIVATIVES | ZENYAKU KOGYO KABUSHIKI KAISHA (JP) | 1990-02-28 | — | — | EP | disclosed |
| US-4804668-A | CARDIOTONIC AGENTS | ZENYAKU KOGYO KABUSHIKI KAISHA (JP) | 1989-02-14 | — | — | US | disclosed |
| EP-0199968-A1 | Thiazole derivatives | ZENYAKU KOGYO KABUSHIKI KAISHA (JP) | 1986-11-05 | — | — | EP | disclosed |