Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.62 |
| ▸ | GAA | P10253 | 2/20 | 0.62 |
| ▸ | TSHR | P16473 | 2/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.62 |
| ▸ | TP53 | P04637 | 2/20 | 0.62 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.47 |
| ▸ | AKT1 | P31749 | 1/20 | 0.45 |
| ▸ | CNR2 | P34972 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8798858 | 0.84 | MAPT (0.47) | MAPTSMN1; SMN2GAATSHRALDH1A1 | |
| SCHEMBL21914346 | 0.82 | MAPT (0.64) | MAPTSMN1; SMN2GAATSHRALDH1A1 | |
| SCHEMBL27890937 | 0.82 | MAPT (0.64) | MAPTSMN1; SMN2GAATSHRALDH1A1 | |
| SCHEMBL7802783 | 0.82 | MAPT (0.55) | MAPTSMN1; SMN2GAATSHRALDH1A1 | |
| SCHEMBL7959133 | 0.82 | ALDH1A1 (0.46) | MAPTSMN1; SMN2GAATSHRALDH1A1 | |
| SCHEMBL5138313 | 0.81 | MAPT (0.53) | MAPTSMN1; SMN2GAATSHRALDH1A1 | |
| SCHEMBL1001435 | 0.80 | TSHR (0.56) | MAPTSMN1; SMN2GAATSHRALDH1A1 | |
| SCHEMBL10347642 | 0.79 | AKT1 (0.61) | MAPTSMN1; SMN2TSHRALDH1A1TP53 | |
| SCHEMBL24050331 | 0.78 | GAA (0.53) | MAPTSMN1; SMN2GAATSHRALDH1A1 | |
| SCHEMBL18281547 | 0.78 | MAPT (0.69) | MAPTSMN1; SMN2GAATSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0166697-B1 | AROYL SUBSTITUTED DIHYDRO-1,4-THIAZINES | CIBA-GEIGY AG (CH) | 1990-05-09 | — | — | EP | disclosed |
| EP-0153890-B1 | DERIVATIVES OF 3-PHENYL-2-PROPENAMINE, THEIR PREPARATION AND MEDICINES CONTAINING THEM | RHONE-POULENC SANTE (FR) | 1989-01-04 | — | — | EP | disclosed |
| US-4755599-A | 3-phenyl-2-propeneamine derivatives, their preparation and composition containing them | RHONE-POULENC SANTE (FR) | 1988-07-05 | — | — | US | disclosed |
| US-4686309-A | ANTIDEPRESSANTS | RHONE-POULENC SANTE (FR) | 1987-08-11 | — | — | US | disclosed |
| EP-0153890-A2 | Derivatives of 3-phenyl-2-propenamine, their preparation and medicines containing them | RHONE-POULENC SANTE (FR) | 1985-09-04 | — | — | EP | disclosed |