Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 6/20 | 0.60 |
| ▸ | DRD2 | P14416 | 5/20 | 0.60 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.60 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.56 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.56 |
| ▸ | HTR2A | P28223 | 2/20 | 0.56 |
| ▸ | HRH1 | P35367 | 2/20 | 0.56 |
| ▸ | HTR2B | P41595 | 2/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.56 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.56 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.56 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.56 |
| ▸ | DRD4 | P21917 | 1/20 | 0.56 |
| ▸ | HRH2 | P25021 | 1/20 | 0.56 |
| ▸ | HTR7 | P34969 | 1/20 | 0.56 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.56 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.56 |
| ▸ | HTR5A | P47898 | 1/20 | 0.56 |
| ▸ | HTR6 | P50406 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1491229 | 0.94 | OPRD1 (0.65) | DRD3DRD2OPRD1CHRM2ADRA2A | |
| Hydrochloric Acid SCHEMBL27914610 | 0.92 | OPRD1 (0.64) | DRD3DRD2OPRD1CHRM2ADRA2A | |
| SCHEMBL1405261 | 0.85 | DRD3 (0.76) | DRD3DRD2OPRD1CHRM2ADRA2A | |
| SCHEMBL20039912 | 0.85 | OPRD1 (0.64) | DRD3DRD2OPRD1CHRM2ADRA2A | |
| SCHEMBL13845055 | 0.85 | DRD3 (0.76) | DRD3DRD2OPRD1CHRM2ADRA2A | |
| SCHEMBL6618656 | 0.84 | DRD3 (0.63) | DRD3DRD2OPRD1CHRM2ADRA2A | |
| Hydrochloric Acid SCHEMBL5113093 | 0.84 | DRD3 (0.74) | DRD3DRD2OPRD1CHRM2ADRA2A | |
| SCHEMBL6617567 | 0.83 | DRD2 (0.63) | DRD3DRD2OPRD1CHRM2ADRA2A | |
| Hydrochloric Acid SCHEMBL6475984 | 0.82 | DRD3 (0.73) | DRD3DRD2OPRD1CHRM2ADRA2A | |
| SCHEMBL10760285 | 0.82 | DRD2 (0.64) | DRD3DRD2CYP2D6LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0094159-B1 | DIHYDROPYRIDINE DERIVATIVES, THEIR PRODUCTION AND USE | Takeda Chemical Industries, Ltd. (JP) | 1990-03-14 | — | — | EP | disclosed |
| US-4892875-A | HYPOTENSIVE, RENAL VASODILATION | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1990-01-09 | — | — | US | disclosed |
| EP-0094159-A1 | Dihydropyridine derivatives, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1983-11-16 | — | — | EP | disclosed |