Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.45 |
| ▸ | RBP4 | P02753 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.40 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | GNE | Q9Y223 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.38 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.38 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | TARDBP | Q13148 | 1/20 | 0.38 |
| ▸ | HSD17B14 | Q9BPX1 | 1/20 | 0.37 |
| ▸ | GBA1 | P04062 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6756872 | 0.98 | RBP4 (0.44) | PIM2RBP4HSD11B1FFAR4ALDH1A1 | |
| SCHEMBL31078509 | 0.83 | PIM2 (0.47) | PIM2RBP4ALDH1A1CSNK2A2CSNK2A1 | |
| SCHEMBL4821896 | 0.83 | KMO (0.55) | PIM2RBP4ALDH1A1HPGDPOLB | |
| SCHEMBL24993369 | 0.81 | AOC3 (0.43) | PIM2HSD11B1FFAR4TARDBPKMT2A | |
| SCHEMBL31301445 | 0.81 | RBP4 (0.43) | RBP4TARDBP | |
| SCHEMBL24323742 | 0.81 | NPC1 (0.41) | PIM2HSD11B1ALDH1A1KMT2AKDM4E | |
| SCHEMBL31014743 | 0.79 | NPC1 (0.40) | PIM2HSD11B1GBA1KMT2AKDM4E | |
| SCHEMBL31015413 | 0.79 | AOC3 (0.42) | PIM2HSD11B1FFAR4TARDBPKDM4E | |
| SCHEMBL20031106 | 0.78 | RBP4 (0.54) | RBP4 | |
| SCHEMBL31301321 | 0.77 | RBP4 (0.48) | RBP4FFAR4KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0227026-B1 | PYRAZINE DERIVATIVE, A PROCESS FOR PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION THEREFROM | Hokuriku Pharmaceutical Co.,Ltd (JP) | 1990-04-18 | — | — | EP | disclosed |
| US-4792547-A | Pyrazine-2-carboxamide derivatives useful in treating allergic disease | HOKURIKU PHARMACEUTICAL CO., LTD. (JP) | 1988-12-20 | — | — | US | disclosed |
| EP-0227026-A1 | Pyrazine derivative, a process for preparation thereof and pharmaceutical composition therefrom | Hokuriku Pharmaceutical Co.,Ltd (JP) | 1987-07-01 | — | — | EP | disclosed |