SCHEMBL31301445

SCHEMBL31301445

O=C(O)c1cncc(N2CCC(F)(F)CC2)n1

nearest known ligand 0.43

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
RBP4 P02753 1/20 0.43
PTGER4 P35408 1/20 0.40
GSK3A P49840 3/20 0.38
GSK3B P49841 3/20 0.38
TARDBP Q13148 1/20 0.38
SCN10A Q9Y5Y9 2/20 0.37
KIF18A Q8NI77 1/20 0.37
CYP11B1 P15538 3/20 0.36
CYP11B2 P19099 3/20 0.36
ADRA1A P35348 1/20 0.35
CNR2 P34972 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24993522 0.83 DPP4 (0.40) PTGER4GSK3AGSK3BSCN10AKIF18A
SCHEMBL24993358 0.83 KIF18A (0.43) PTGER4GSK3AGSK3BTARDBPSCN10A
SCHEMBL6756872 0.82 RBP4 (0.44) RBP4TARDBP
SCHEMBL10367486 0.81 PIM2 (0.45) RBP4TARDBP
SCHEMBL22616904 0.79 AR (0.44) RBP4TARDBP
SCHEMBL29533186 0.79 AR (0.44) RBP4TARDBP
SCHEMBL24993520 0.79 SCN10A (0.42) PTGER4GSK3AGSK3BTARDBPSCN10A
SCHEMBL24993374 0.79 TARDBP (0.44) GSK3AGSK3BTARDBPSCN10AKIF18A
SCHEMBL31078509 0.78 PIM2 (0.47) RBP4
SCHEMBL4821896 0.78 KMO (0.55) RBP4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4727549-A2 PLASMODIUM FALCIPARUM BLOOD STAGE INHIBITORS University of Georgia Research Foundation, Inc. (US) 2026-04-22 EP disclosed
US-20260097046-A1 PLASMODIUM FALCIPARUM BLOOD STAGE INHIBITORS UNIV GEORGIA (US) 2026-04-09 US disclosed
WO-2024258900-A2 PLASMODIUM FALCIPARUM BLOOD STAGE INHIBITORS UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (US) 2024-12-19 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260097046-A1 PLASMODIUM FALCIPARUM BLOOD STAGE INHIBITORS SUB1, PFN1, HCCS RBP4 2018/4885PTGER4 2726/4885GSK3A 1797/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.