Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | CES1 | P23141 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10366865 | 0.85 | AKR1B1 (0.46) | AKR1B1ALDH1A1GAACES1 | |
| SCHEMBL10366644 | 0.79 | ALDH1A1 (0.51) | AKR1B1ALDH1A1GAACES1 | |
| SCHEMBL14305454 | 0.67 | CYP11B1 (0.54) | — | |
| SCHEMBL11717588 | 0.67 | NPC1 (0.57) | GAA | |
| SCHEMBL10368920 | 0.66 | AKR1B1 (0.45) | AKR1B1 | |
| SCHEMBL10367313 | 0.63 | AKR1B1 (0.45) | AKR1B1 | |
| SCHEMBL10367642 | 0.63 | CES1 (0.62) | ALDH1A1GAACES1 | |
| SCHEMBL10660820 | 0.62 | NPC1 (0.40) | — | |
| SCHEMBL18602615 | 0.62 | ALDH1A1 (0.32) | ALDH1A1 | |
| SCHEMBL1105731 | 0.61 | KMT2A (0.55) | ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0147805-B1 | SPIRO-LINKED PYRROLIDINE-2,5-DIONES AND PROCESS FOR THEIR PREPARATION | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 1990-10-10 | — | — | EP | disclosed |
| US-4593092-A | Spiro-linked pyrrolidin-2,5-dione | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 1986-06-03 | — | — | US | disclosed |
| EP-0147805-A2 | Spiro-linked pyrrolidine-2,5-diones and process for their preparation | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 1985-07-10 | — | — | EP | disclosed |