Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | CES1 | P23141 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10366865 | 0.79 | AKR1B1 (0.46) | ALDH1A1GAACES1AKR1B1 | |
| SCHEMBL10367698 | 0.79 | AKR1B1 (0.38) | ALDH1A1GAACES1AKR1B1 | |
| SCHEMBL8807959 | 0.75 | AKR1B1 (0.36) | AKR1B1 | |
| SCHEMBL10860119 | 0.75 | ALDH1A1 (0.53) | ALDH1A1GAACES1USP2MAP2K1 | |
| SCHEMBL10856173 | 0.75 | AKR1B1 (0.36) | ALDH1A1GAAAKR1B1 | |
| SCHEMBL6746228 | 0.70 | MAP2K1 (0.53) | ALDH1A1GAACES1USP2MAP2K1 | |
| SCHEMBL9194271 | 0.70 | NPC1 (0.44) | AKR1B1 | |
| SCHEMBL28746487 | 0.68 | ALDH1A1 (0.46) | ALDH1A1GAACES1USP2MAP2K1 | |
| SCHEMBL13306376 | 0.67 | SCN9A (0.45) | ALDH1A1GAACES1USP2 | |
| SCHEMBL3349347 | 0.66 | ALDH1A1 (0.38) | ALDH1A1GAACES1USP2MAP2K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-60142984-A | — | — | None | — | — | JP | disclosed |
| EP-0147805-B1 | SPIRO-LINKED PYRROLIDINE-2,5-DIONES AND PROCESS FOR THEIR PREPARATION | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 1990-10-10 | — | — | EP | disclosed |
| US-4593092-A | Spiro-linked pyrrolidin-2,5-dione | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 1986-06-03 | — | — | US | disclosed |
| JP-S60142984-A | NOVEL SPIROPYRROLIDINE-2,5-DIONE DERIVATIVE AND ITS PREPARATION | KYORIN PHARMACEUT CO LTD | 1985-07-29 | — | — | JP | disclosed |
| EP-0147805-A2 | Spiro-linked pyrrolidine-2,5-diones and process for their preparation | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 1985-07-10 | — | — | EP | disclosed |