Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
| ▸ | CASP7 | P55210 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.31 |
| ▸ | POLB | P06746 | 2/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.31 |
| ▸ | CA12 | O43570 | 3/20 | 0.31 |
| ▸ | CA1 | P00915 | 3/20 | 0.31 |
| ▸ | CA2 | P00918 | 3/20 | 0.31 |
| ▸ | CA7 | P43166 | 3/20 | 0.31 |
| ▸ | CA9 | Q16790 | 3/20 | 0.31 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10367367 | 0.74 | ALDH1A1 (0.32) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL6986172 | 0.71 | — | — | |
| SCHEMBL10366235 | 0.68 | ALDH1A1 (0.43) | TSHRALDH1A1HSD17B10LMNATDP1 | |
| SCHEMBL10829313 | 0.66 | LMNA (0.40) | LMNACA1CA2NPC1RAB9A | |
| SCHEMBL6729729 | 0.65 | CHRM3 (0.38) | CHRM3TSHRALDH1A1HSD17B10LMNA | |
| SCHEMBL27647692 | 0.64 | CHRM3 (0.44) | CHRM3TSHRLMNATDP1CA12 | |
| SCHEMBL4922594 | 0.64 | CHRM3 (0.44) | CHRM3TSHRALDH1A1HSD17B10TDP1 | |
| SCHEMBL22226391 | 0.64 | ALDH1A1 (0.51) | ALDH1A1HSD17B10LMNAKDM4EALOX15 | |
| SCHEMBL6994905 | 0.64 | KDM4E (0.39) | TSHRALDH1A1HSD17B10LMNAKDM4E | |
| SCHEMBL10368421 | 0.64 | CES2 (0.42) | TSHRALDH1A1ALOX15TDP1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0166697-B1 | AROYL SUBSTITUTED DIHYDRO-1,4-THIAZINES | CIBA-GEIGY AG (CH) | 1990-05-09 | — | — | EP | disclosed |
| EP-0166697-A2 | Aroyl substituted dihydro-1,4-thiazines | CIBA-GEIGY AG (CH) | 1986-01-02 | — | — | EP | disclosed |