Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | CASP3 | P42574 | 2/20 | 0.43 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.43 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.43 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | RPS6KA2 | Q15349 | 1/20 | 0.42 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10367179 | 0.79 | NPC1 (0.43) | SMN1; SMN2ALDH1A1KMT2AHSD17B10NPC1 | |
| SCHEMBL10367180 | 0.79 | NPC1 (0.43) | SMN1; SMN2ALDH1A1KMT2AHSD17B10NPC1 | |
| SCHEMBL10366277 | 0.76 | ALDH1A1 (0.51) | SMN1; SMN2ALDH1A1KMT2AHSD17B10NPC1 | |
| SCHEMBL10922305 | 0.75 | SMN1; SMN2 (0.44) | SMN1; SMN2ALDH1A1KMT2AHSD17B10NPC1 | |
| SCHEMBL7345361 | 0.74 | SMN1; SMN2 (0.63) | SMN1; SMN2ALDH1A1KMT2AHSD17B10NPC1 | |
| SCHEMBL10367165 | 0.71 | NPC1 (0.56) | SMN1; SMN2ALDH1A1KMT2ANPC1RAB9A | |
| SCHEMBL24099161 | 0.70 | ALDH1A1 (0.64) | SMN1; SMN2ALDH1A1KMT2AHSD17B10NPC1 | |
| SCHEMBL696173 | 0.70 | GSK3B (0.71) | SMN1; SMN2ALDH1A1KMT2AHSD17B10NPC1 | |
| SCHEMBL24099262 | 0.69 | ALDH1A1 (0.67) | SMN1; SMN2ALDH1A1KMT2AHSD17B10NPC1 | |
| SCHEMBL469591 | 0.67 | CYP1A2 (0.61) | SMN1; SMN2ALDH1A1KMT2ANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0166697-B1 | AROYL SUBSTITUTED DIHYDRO-1,4-THIAZINES | CIBA-GEIGY AG (CH) | 1990-05-09 | — | — | EP | disclosed |
| EP-0166697-A2 | Aroyl substituted dihydro-1,4-thiazines | CIBA-GEIGY AG (CH) | 1986-01-02 | — | — | EP | disclosed |